Trial reportWorld neurosurgery2017
Intraoperative Near-Infrared Optical Contrast Can Localize Brain Metastases.
Trial report in World neurosurgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Surface-Registration Frameless Stereotactic Navigation Is Less Accurate During Prone Surgeries: Intraoperative Near-Infrared Visualization Using Second Window Indocyanine Green Offers an Adjunct.Molecular imaging and biology · 2020Trial
- Evaluation of Diagnostic Accuracy Following the Coadministration of Delta-Aminolevulinic Acid and Second Window Indocyanine Green in Rodent and Human Glioblastomas.Molecular imaging and biology · 2020Trial
- Tumour Localisation Technologies in Colorectal Cancer Surgery: A Scoping Review of Marking and Detection Methods.Diagnostics (Basel, Switzerland) · 2026Review
- Image-Guided Brain Tumor Surgery.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Review
- Comparing spatial distributions of ALA-PpIX and indocyanine green in a whole pig brain glioma model using 3D fluorescence cryotomography.Journal of biomedical optics · 2025Article
- Review
- Utility of intraoperative fluorescence imaging with indocyanine green for diagnosing spinal schwannoma: A case report.Surgical neurology international · 2024Article
- The diagnostic accuracy of intraoperative differentiation and delineation techniques in brain tumours.Discover oncology · 2022Review
- Algorithms and instrumentation for rapid spatial frequency domain fluorescence diffuse optical imaging.Journal of biomedical optics · 2022Article
- Quantifying the Photochemical Damage Potential of Contrast-Enhanced Fluorescence Imaging Products: Singlet Oxygen Production.Photochemistry and photobiology · 2022Article
- Review
- Utility of intraoperative real-time near-infrared fluorescence surgery for spinal schwannoma.Neurosurgical focus: Video · 2022Article
- Intraoperative Real-Time Near-Infrared Image-Guided Surgery to Identify Intracranial MeningiomasFrontiers in neuroscience · 2022Article
- Surgical advances in the management of brain metastases.Neuro-oncology advances · 2021Article
- Second window ICG predicts gross-total resection and progression-free survival during brain metastasis surgery.Journal of neurosurgery · 2021Article
- Second-Window Indocyanine Green for Visualization of Hemangioblastoma: A Case Report With Two-Dimensional Operative Video.Operative neurosurgery (Hagerstown, Md.) · 2021Article
- Indocyanine Green-Guided Pediatric Tumor Resection: Approach, Utility, and Challenges.Frontiers in pediatrics · 2021Article
- Near-Infrared Imaging with Second-Window Indocyanine Green in Newly Diagnosed High-Grade Gliomas Predicts Gadolinium Enhancement on Postoperative Magnetic Resonance Imaging.Molecular imaging and biology · 2020Article
- Combined fluorescence-guided surgery and photodynamic therapy for glioblastoma multiforme using cyanine and chlorin nanocluster.Journal of neuro-oncology · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionApproximately 100,000 brain metastases are diagnosed annually in the United States. Our laboratory has pioneered a novel technique, second window indocyanine green (SWIG), which allows for real-time intraoperative visualization of brain metastasis through normal brain parenchyma and intact dura.
methodsThirteen patients with intraparenchymal brain metastases were administered indocyanine green (ICG) at 5 mg/kg the day before surgery. A near-infrared (NIR)- capable camera was used intraoperatively to identify the tumor and to inspect surgical margins. Neuropathology was used to assess the accuracy and precision of the fluorescent dye for identifying tumor.
resultsICG was infused at 24.7 ± 3.45 hours before visualization. All 13 metastases fluoresced with an average signal-to-background ratio (SBR) of 6.62. The SBR with the dura intact was 67.2% of the mean SBR once the dura was opened. The NIR signal could be visualized through normal brain parenchyma up to 7 mm. For the 39 total specimens, the mean SBR for tumor specimens (n = 28) was 6.9, whereas the SBR for nontumor specimens (n = 11) was 3.7. The sensitivity, specificity, positive predictive value, and negative predictive value of NIR imaging for tumor was 96.4%, 27.3%, 77.1%, and 75.0%. DISCUSSION: SWIG relies on the passive accumulation of dye in abnormal tumor tissue via the enhanced permeability and retention effect. It provides strong NIR optical contrast, which can be used to localize tumors before dural opening. The use of SWIG for margin assessment remains limited by its lack of specificity (high false-positive rate); however, ongoing improvements in imaging parameters show great potential to reduce false-positive results.
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