Evidence map›Paper›PMID 28669618›Full record

ArticleVaccine2017

Immunization of Zika virus envelope protein domain III induces specific and neutralizing immune responses against Zika virus.

Ming Yang, Matthew Dent, Huafang Lai, Haiyan Sun, Qiang Chen

Abstract read
In one paragraph

Article in Vaccine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 111 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. A Lambda-evo (λApplied microbiology and biotechnology · 2025
    Article
  8. Article
  9. An Overview of Zika Virus and Zika Virus Induced Neuropathies.International journal of molecular sciences · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Zika Virus Envelope Protein Domain III Produced inDiagnostics (Basel, Switzerland) · 2022
    Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ming YangThe Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Matthew DentThe Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Huafang LaiThe Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Haiyan SunThe Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Qiang ChenThe Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA; School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA. Electronic address: qiang.chen.4@asu.edu.
Arizona State University · US

Funding

Bifunctional antibodies with targeted CNS delivery against West Nile VirusR33AI101329 · NIAID · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI CHEN, QIANG · 2014 to 2016
$1.3M
NIAID NIH HHS R33 AI101329
6 · The paper itself

Abstract

In this study, we described the generation and immunogenicity of the Zika Virus (ZIKV) envelope protein (E) domain III (DIII) as a protein subunit vaccine candidate. ZIKV EDIII (zEDIII) was rapidly produced in E. coli in inclusion bodies. ZIKV EDIII was solubilized, refolded and purified to >95% homogeneity with a one-step Ni

Indexed as

AnimalsAntibodies, NeutralizingAntibodies, ViralFemaleImmunization ScheduleImmunoglobulin GInterferon-gammaInterleukin-4Interleukin-6Leukocytes, MononuclearMice, Inbred C57BLProtein DomainsSpleenVaccines, SubunitViral VaccinesZika VirusAntibodies, NeutralizingAntibodies, ViralImmunoglobulin GInterferon-gammaInterleukin-4Interleukin-6interleukin-6, mouseVaccines, SubunitViral VaccinesAntibody-dependent enhancement (ADE)AntigenDomain III (DIII)Envelope proteinNeutralizing immunityVaccineZika virus

Identifiers

PMID28669618
PMCPMC5546088
OpenAlexW2726244132

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.