Evidence map›Paper›PMID 28669606›Full record

Trial reportClinical colorectal cancer2018

Dose-response Effects of Aerobic Exercise Among Colon Cancer Survivors: A Randomized Phase II Trial.

Justin C Brown, Andrea B Troxel, Bonnie Ky, Nevena Damjanov, Babette S Zemel, Michael R Rickels, Andrew D Rhim, Anil K Rustgi, Kerry S Courneya, Kathryn H Schmitz

Open access · bronzeAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical colorectal cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 10 pooled it
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 10 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Justin C BrownDivision of Population Science & Gastrointestinal Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA. Electronic address: justinc_brown@dfci.harvard.edu.
Andrea B TroxelDepartment of Population Health, NYU School of Medicine, New York, NY.
Bonnie KyDivision of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA.
Nevena DamjanovDivision of Medical Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA.
Babette S ZemelDivision of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA.
Michael R RickelsDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania, Philadelphia, PA.
Andrew D RhimDepartment of Gastroenterology, Hepatology and Nutrition, M.D. Anderson Cancer Center, Houston, TX.
Anil K RustgiDivision of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA.
Kerry S CourneyaDepartment of Physical Activity and Recreation, University of Alberta, Edmonton, Alberta, Canada.
Kathryn H SchmitzDepartment of Public Health Science, College of Medicine, Penn State College of Medicine, Hershey, PA.
University of Pennsylvania · USChildren's Hospital of Philadelphia · USDana-Farber Cancer Institute · USNew York University · USPennsylvania State University · USThe University of Texas MD Anderson Cancer Center · USUniversity of Alberta · CA

Funding

Institutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9M
The Women In Steady Exercise Research (WISER) SurwVor TrialU54CA155850 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CHODOSH, LEWIS A · 2011 to 2015
$9.1M
The COURAGE Trial: Colon Recurrence and Aerobic Exercise: A Feasibility StudyR21CA182767 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SCHMITZ, KATHRYN H. · 2014 to 2015
$377k
Effects of Exercise on Visceral Adiposity & Hyperinsulinemia in Colon Cancer SurvivorF31CA192560 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BROWN, JUSTIN C · 2015 to 2016
$69k
NCATS NIH HHS UL1 TR000003NCI NIH HHS F31 CA192560NCI NIH HHS R21 CA182767NCI NIH HHS U54 CA155850
6 · The paper itself

Abstract

backgroundObservational studies suggest that higher volumes of physical activity are associated with a lower risk of disease recurrence among survivors of colon cancer. However, the feasibility and safety of prescribing higher volumes of physical activity to survivors of colon cancer are unknown. Furthermore, the pathways through which exercise may reduce disease recurrence are unknown. PATIENTS AND

methodsSurvivors of stage I to III colon cancer were randomized to usual-care control, 150 minutes per week of aerobic exercise (low-dose), or 300 minutes per week of aerobic exercise (high-dose). Changes in soluble intercellular adhesion molecule-1 and vascular adhesion molecule-1 prognostic biomarkers were examined.

resultsFrom January 2015 to February 2016, 39 patients were enrolled (n = 13 usual-care control; n = 14 low-dose; n = 12 high-dose), and 38 participants completed the study (97% follow-up). Over 6 months, the low-dose group completed 142 minutes per week (92.8% adherence), and the high-dose group completed 247 minutes per week (89.0% adherence) of exercise. Compared with the control group, changes in soluble intercellular adhesion molecule-1 were -134.9 ng/mL (95% confidence interval, -238.1 to -31.6 ng/mL) in the low-dose group and -114.8 ng/mL (95% confidence interval, -222.5 to -7.1 ng/mL) in the high-dose group (linear P

conclusionHigher volumes of moderate-intensity aerobic exercise, up to 300 minutes per week, are feasible, safe, and elicit favorable changes in prognostic biomarkers among patients recently treated for stage I to III colon cancer. These data can be used to guide clinical recommendations for patients, and inform future trials.

Indexed as

Cancer SurvivorsColonic NeoplasmsAdultAgedAmine Oxidase (Copper-Containing)Biomarkers, TumorCell Adhesion MoleculesExerciseExercise TherapyFemaleHumansIntercellular Adhesion Molecule-1MaleMiddle AgedNeoplasm Recurrence, LocalAmine Oxidase (Copper-Containing)AOC3 protein, humanBiomarkers, TumorCell Adhesion MoleculesICAM1 protein, humanIntercellular Adhesion Molecule-1BiomarkersEnergy balanceLifestylePhysical activitySurvivorship

Identifiers

PMID28669606
PMCPMC5733696
OpenAlexW2723787463

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.