Evidence map›Paper›PMID 28669194›Full record

ArticleMolecular pharmaceutics2019

Nanoparticle Properties for Delivery to Cartilage: The Implications of Disease State, Synovial Fluid, and Off-Target Uptake.

Shannon Brown, Jake Pistiner, Isaac M Adjei, Blanka Sharma

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 94 citations in OpenAlex.

  1. Article
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  10. Article
  11. Liposome-Based Interventions in Knee Osteoarthritis.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  12. Review
  13. Review
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  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Functional Nanomaterials for the Treatment of Osteoarthritis.International journal of nanomedicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shannon BrownJ. Crayton Pruitt Family Department of Biomedical Engineering , University of Florida , 1275 Center Drive , Biomedical Sciences Building JG-56, P.O. Box 116131, Gainesville , Florida 32611-6131 , United States.
Jake PistinerJ. Crayton Pruitt Family Department of Biomedical Engineering , University of Florida , 1275 Center Drive , Biomedical Sciences Building JG-56, P.O. Box 116131, Gainesville , Florida 32611-6131 , United States.
Isaac M AdjeiJ. Crayton Pruitt Family Department of Biomedical Engineering , University of Florida , 1275 Center Drive , Biomedical Sciences Building JG-56, P.O. Box 116131, Gainesville , Florida 32611-6131 , United States.
Blanka SharmaJ. Crayton Pruitt Family Department of Biomedical Engineering , University of Florida , 1275 Center Drive , Biomedical Sciences Building JG-56, P.O. Box 116131, Gainesville , Florida 32611-6131 , United States.
University of Florida · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
NCATS NIH HHS UL1 TR001427
6 · The paper itself

Abstract

A major hurdle limiting the ability to treat and cure osteoarthritis, a common and debilitating disease, is rapid joint clearance and limited cartilage targeting of intra-articular therapies. Nanoscale drug carriers have the potential to improve therapeutic targeting and retention in the joint after direct injection; however, there still lacks a fundamental understanding of how the physicochemical properties of nanoparticles (NPs) influence localization to the degenerating cartilage and how joint conditions such as disease state and synovial fluid impact NP biodistribution. The goal of this study was to assess how physicochemical properties of NPs influence their interactions with joint tissues and, ultimately, cartilage localization. Ex vivo models of joint tissues were used to study how poly(lactide- co-glycolide) (PLGA) and polystyrene (PS) NP size, charge, and surface chemistry influence cartilage retention under normal and disease-mimicking conditions. Of the particles investigated, PLGA NPs surface-modified with a quaternary ammonium cation had the greatest retention within cartilage explants; however, retention was diminished 2- to 2.9-fold in arthritic tissue and in the presence of synovial fluid. Interactions with synovial fluid induced changes to NP surface properties and colloidal stability in vitro. The impact of NP charge on "off-target" synoviocyte uptake was also dependent on synovial fluid interactions. The results suggest that the design of nanocarriers for targeted drug delivery within the joint cannot be based on a single parameter such as zeta potential or size, and that the fate of injected delivery systems will likely be influenced by the disease state of the joint and the presence of synovial fluid.

Indexed as

FemaleHumansNanoparticlesOsteoarthritisPlacentaPolylactic Acid-Polyglycolic Acid CopolymerPolystyrenesPregnancySynovial FluidPolylactic Acid-Polyglycolic Acid CopolymerPolystyrenescartilagedrug deliveryex vivo modelsintra-articularNanoparticleosteoarthritissynovium

Identifiers

PMID28669194
PMCPMC7147813
OpenAlexW2730852043

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.