ReviewClinical autonomic research : official journal of the Clinical Autonomic Research Society2017
Typical vasovagal syncope as a "defense mechanism" for the heart by contrasting sympathetic overactivity.
Review in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 39 citations in OpenAlex.
- Hierarchical Studies in TRAP2 Mice Demonstrate that Neuronal Activation and Mitochondrial Networks Integration Constitute the Key Mechanism Underlying Painful Syncope.Neuroscience bulletin · 2026Article
- Comparison of heart rate variability, hemodynamic, metabolic and inflammatory parameters in various phases of decompansatory hemorrhagic shock of normal and vagotomized conscious male rats.BMC cardiovascular disorders · 2024Article
- Cardiac Geometry and Function in Patients with Reflex Syncope.Journal of clinical medicine · 2024Review
- Article
- Asystole on loop recorder in patients with unexplained syncope and negative tilt testing: age distribution and clinical predictors.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
- Cardioneuroablation for the Treatment of Vasovagal Syncope Induced by Chili Pepper Stimulation: A Case Report.International medical case reports journal · 2024Article
- Sleep syncope: a new clinical entity or just a vasovagal syncope during wakefulness after sleep onset?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Neurally mediated syncope starting in old age does not appear to be unique to humans: new perspective.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Underlying hemodynamic differences are associated with responses to tilt testing.Scientific reports · 2021Article
- Hemodynamics of tonic immobility in the American alligator (Alligator mississippiensis) identified through Doppler ultrasonography.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Article
- Sympathetic mechanisms in an animal model of vasovagal syncope.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Article
- Alterations of brain network hubs in reflex syncope: Evidence from a graph theoretical analysis based on DTI.Brain and behavior · 2018Article
- The target of vasovagal syncope is hemostasis and not heart protection.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2017Article
- Considering Needle Phobia among Adult Patients During Mass COVID-19 Vaccinations.Journal of primary care & community healthReview
- Impact of Yoga on Cardiac Autonomic Function and Arrhythmias.Journal of atrial fibrillationArticle
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Many observations suggest that typical (emotional or orthostatic) vasovagal syncope (VVS) is not a disease, but rather a manifestation of a non-pathological trait. Some authors have hypothesized this type of syncope as a "defense mechanism" for the organism and a few theories have been postulated. Under the human violent conflicts theory, the VVS evolved during the Paleolithic era only in the human lineage. In this evolutionary period, a predominant cause of death was wounding by a sharp object. This theory could explain the occurrence of emotional VVS, but not of the orthostatic one. The clot production theory suggests that the vasovagal reflex is a defense mechanism against hemorrhage in mammals. This theory could explain orthostatic VVS, but not emotional VVS. The brain self-preservation theory is mainly based on the observation that during tilt testing a decrease in cerebral blood flow often precedes the drop in blood pressure and heart rate. The faint causes the body to take on a gravitationally neutral position, and thereby provides a better chance of restoring brain blood supply. However, a decrease in cerebral blood flow has not been demonstrated during negative emotions, which trigger emotional VVS. Under the heart defense theory, the vasovagal reflex seems to be a protective mechanism against sympathetic overactivity and the heart is the most vulnerable organ during this condition. This appears to be the only unifying theory able to explain the occurrence of the vasovagal reflex and its associated selective advantage, during both orthostatic and emotional stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.