ReviewPain and therapy2017
Pain as a First Manifestation of Paraneoplastic Neuropathies: A Systematic Review and Meta-Analysis.
Review in Pain and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Repetitive Magnetic Stimulation for the Management of Peripheral Neuropathic Pain: A Systematic Review.Advances in therapy · 2020Pooled it
- Alcohol-related peripheral neuropathy: a systematic review and meta-analysis.Journal of neurology · 2019Pooled it
- Quality of Life in Painful Peripheral Neuropathies: A Systematic Review.Pain research & management · 2019Pooled it
- Inflammatory neuropathy in mouse and primate models of colorectal cancer.Nature communications · 2026Article
- People's experiences living with peripheral neuropathy: a qualitative study.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- [Diagnostics and treatment of clinically relevant paraneoplastic syndromes].Schmerz (Berlin, Germany) · 2022Review
- Successful Treatment of Paraneoplastic Neuropathy and Pruritis With Scrambler Therapy: A Case Report.Cureus · 2022Article
- Sudomotor dysfunction in patients with gluten neuropathy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Autonomic Regulation of Nociceptive and Immunologic Changes in a Mouse Model of Complex Regional Pain Syndrome.The journal of pain · 2022Article
- External Treatment With Chinese Herbal Medicine for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2022Review
- Pharmacological Management of Painful Peripheral Neuropathies: A Systematic Review.Pain and therapy · 2021Review
- IL-6 signaling mediates the germinal center response, IgM production and nociceptive sensitization in male mice after tibia fracture.Brain, behavior, and immunity · 2021Article
- Immunophenotypical characterization of paraneoplastic neurological syndrome patients: a multicentric study.Journal of biosciences · 2021Article
- Statins and Neuropathic Pain: A Narrative Review.Pain and therapy · 2020Review
- Frontiers in Pain Research: A Scope of Its Focus and Content.Frontiers in pain research (Lausanne, Switzerland) · 2020Article
- Exploring the Possible Mechanism and Drug Targets of Huang-Qi-Gui-Zhi-Wu-Wu Decoction for the Treatment of Chemotherapy-Induced Peripheral Neuropathy on Network Pharmacology.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Pain in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Systematic Review and Meta-Analysis.Pain and therapy · 2019Review
- Scientific Advances in and Clinical Approaches to Small-Fiber Polyneuropathy: A Review.JAMA neurology · 2019Article
- The Novel C5aR Antagonist DF3016A Protects Neurons Against Ischemic Neuroinflammatory Injury.Neurotoxicity research · 2019Article
- Psychological Aspects and Quality of Life in Chronic Pain.Pain research & management · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionParaneoplastic neurological syndromes (PNS) consist of a heterogeneous group of neurological disorders triggered by cancer. The aim of this systematic review is to estimate the reported prevalence of pain in patients with paraneoplastic peripheral neuropathy (PPN).
methodsA systematic computer-based literature search was conducted on PubMed database.
resultsOur search strategy resulted in the identification of 126 articles. After the eligibility assessment, 45 papers met the inclusion criteria. Full clinical and neurophysiological data were further extracted and involved 92 patients with PPN (54.5% males, mean age 60.0 ± 12.2 years). The commonest first manifestation of PPN is sensory loss (67.4%), followed by pain (41.3%), weakness (22.8%), and sensory ataxia (20.7%). In 13.0% of the cases, pain was the sole first manifestation of the PPN. During the course of the PPN, 57.6% of the patients may experience pain secondary to the neuropathy.
conclusionsPain is very prevalent within PPN. Pain specialists should be aware of this. Detailed history-taking, full clinical examination, and requesting nerve conduction studies might lead to an earlier diagnosis of an underlying malignancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.