Evidence map›Paper›PMID 28668914›Full record

Trial reportAmerican journal of critical care : an official publication, American Association of Critical-Care Nurses2017

Safety and Acceptability of Patient-Administered Sedatives During Mechanical Ventilation.

Linda L Chlan, Debra J Skaar, Mary F Tracy, Sarah M Hayes, Breanna D Hetland, Kay Savik, Craig R Weinert

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of critical care : an official publication, American Association of Critical-Care Nurses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 4 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 4 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. "Sedation is tricky": A qualitative content analysis of nurses' perceptions of sedation administration in mechanically ventilated intensive care unit patients.Australian critical care : official journal of the Confederation of Australian Critical Care Nurses · 2018
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Linda L ChlanLinda L. Chlan is associate dean for nursing research, Mayo Clinic, Rochester, Minnesota. Debra J. Skaar is an associate professor, College of Pharmacy, Kay Savik is a senior statistician, School of Nursing (retired), and Craig R. Weinert is an associate professor, School of Medicine, University of Minnesota, Minneapolis, Minnesota. Mary F. Tracy was a critical care clinical nurse specialist, University of Minnesota Medical Center, Minneapolis, Minnesota. Sarah M. Hayes is a pharmacy resident, North Memorial Medical Center, Minneapolis, Minnesota. Breanna D. Hetland is a postdoctoral fellow, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio. Chlan.Linda@mayo.edu.
Debra J SkaarLinda L. Chlan is associate dean for nursing research, Mayo Clinic, Rochester, Minnesota. Debra J. Skaar is an associate professor, College of Pharmacy, Kay Savik is a senior statistician, School of Nursing (retired), and Craig R. Weinert is an associate professor, School of Medicine, University of Minnesota, Minneapolis, Minnesota. Mary F. Tracy was a critical care clinical nurse specialist, University of Minnesota Medical Center, Minneapolis, Minnesota. Sarah M. Hayes is a pharmacy resident, North Memorial Medical Center, Minneapolis, Minnesota. Breanna D. Hetland is a postdoctoral fellow, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio.
Mary F TracyLinda L. Chlan is associate dean for nursing research, Mayo Clinic, Rochester, Minnesota. Debra J. Skaar is an associate professor, College of Pharmacy, Kay Savik is a senior statistician, School of Nursing (retired), and Craig R. Weinert is an associate professor, School of Medicine, University of Minnesota, Minneapolis, Minnesota. Mary F. Tracy was a critical care clinical nurse specialist, University of Minnesota Medical Center, Minneapolis, Minnesota. Sarah M. Hayes is a pharmacy resident, North Memorial Medical Center, Minneapolis, Minnesota. Breanna D. Hetland is a postdoctoral fellow, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio.
Sarah M HayesLinda L. Chlan is associate dean for nursing research, Mayo Clinic, Rochester, Minnesota. Debra J. Skaar is an associate professor, College of Pharmacy, Kay Savik is a senior statistician, School of Nursing (retired), and Craig R. Weinert is an associate professor, School of Medicine, University of Minnesota, Minneapolis, Minnesota. Mary F. Tracy was a critical care clinical nurse specialist, University of Minnesota Medical Center, Minneapolis, Minnesota. Sarah M. Hayes is a pharmacy resident, North Memorial Medical Center, Minneapolis, Minnesota. Breanna D. Hetland is a postdoctoral fellow, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio.
Breanna D HetlandLinda L. Chlan is associate dean for nursing research, Mayo Clinic, Rochester, Minnesota. Debra J. Skaar is an associate professor, College of Pharmacy, Kay Savik is a senior statistician, School of Nursing (retired), and Craig R. Weinert is an associate professor, School of Medicine, University of Minnesota, Minneapolis, Minnesota. Mary F. Tracy was a critical care clinical nurse specialist, University of Minnesota Medical Center, Minneapolis, Minnesota. Sarah M. Hayes is a pharmacy resident, North Memorial Medical Center, Minneapolis, Minnesota. Breanna D. Hetland is a postdoctoral fellow, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio.
Kay SavikLinda L. Chlan is associate dean for nursing research, Mayo Clinic, Rochester, Minnesota. Debra J. Skaar is an associate professor, College of Pharmacy, Kay Savik is a senior statistician, School of Nursing (retired), and Craig R. Weinert is an associate professor, School of Medicine, University of Minnesota, Minneapolis, Minnesota. Mary F. Tracy was a critical care clinical nurse specialist, University of Minnesota Medical Center, Minneapolis, Minnesota. Sarah M. Hayes is a pharmacy resident, North Memorial Medical Center, Minneapolis, Minnesota. Breanna D. Hetland is a postdoctoral fellow, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio.
Craig R WeinertLinda L. Chlan is associate dean for nursing research, Mayo Clinic, Rochester, Minnesota. Debra J. Skaar is an associate professor, College of Pharmacy, Kay Savik is a senior statistician, School of Nursing (retired), and Craig R. Weinert is an associate professor, School of Medicine, University of Minnesota, Minneapolis, Minnesota. Mary F. Tracy was a critical care clinical nurse specialist, University of Minnesota Medical Center, Minneapolis, Minnesota. Sarah M. Hayes is a pharmacy resident, North Memorial Medical Center, Minneapolis, Minnesota. Breanna D. Hetland is a postdoctoral fellow, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio.
University of Minnesota · USCase Western Reserve University · USFairview Southdale Hospital · USNorth Memorial Medical Center · USUniversity of Minnesota Medical Center · US

Funding

Symptom Management and Palliative Care Research in Adults with Advanced DiseaseT32NR014213 · NINR · CASE WESTERN RESERVE UNIVERSITY · PI DALY, BARBARA · 2013 to 2017
$1.6M
Testing the feasibility of patient-controlled sedation in ventilated ICU patientsR21NR012795 · NINR · UNIVERSITY OF MINNESOTA · PI WEINERT, CRAIG R · 2012 to 2013
$377k
NINR NIH HHS R21 NR012795NINR NIH HHS T32 NR014213
6 · The paper itself

Abstract

backgroundSafety and acceptability of sedative self-administration by patients receiving mechanical ventilation is unknown.

objectivesTo determine if self-administration of dexmedetomidine by patients is safe and acceptable for self-management of anxiety during ventilatory support.

methodsIn a pilot trial in 3 intensive care units, 17 intubated patients were randomly assigned to dexmedetomidine and 20 to usual care. Dexmedetomidine was administered via standard pumps for patient-controlled analgesia, with a basal infusion (0.1-0.7 μg/kg per hour) titrated by the number of patient-triggered doses (0.25 μg/kg per dose). Safety goals were heart rate greater than 40/min, systolic blood pressure greater than 80 mm Hg, and diastolic blood pressure greater than 50 mm Hg. Acceptability was based on patients' self-reported satisfaction and ability to administer the sedative. A 100-mm visual analog scale was used daily to assess patients' anxiety.

resultsThe sample was 59% male and 89% white. Mean values were age, 50.6 years; score on the Acute Physiology and Chronic Health Evaluation, 60.1; and protocol duration, 3.4 days. Five dexmedetomidine patients had blood pressure and/or heart rate lower than safety parameters, necessitating short-term treatment. Nurses' adherence to reporting of safety parameters was 100%; adherence to the dexmedetomidine titration algorithm was 73%. Overall baseline anxiety score was 38.4 and did not change significantly (β

conclusionsFor select patients, self-administration of dexmedetomidine is safe and acceptable.

Indexed as

Patient SatisfactionAdultAgedAnxietyBlood PressureDexmedetomidineFemaleGuideline AdherenceHeart RateHumansHypnotics and SedativesInfusion PumpsIntensive Care UnitsMaleMiddle AgedPilot ProjectsDexmedetomidineHypnotics and Sedatives

Identifiers

PMID28668914
PMCPMC5576507
OpenAlexW2728332492

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.