Evidence map›Paper›PMID 28668830›Full record

ArticleAnticancer research2017

Increased Nicotinamide Phosphoribosyltransferase and Cystathionine-β-Synthase in Renal Oncocytomas, Renal Urothelial Carcinoma, and Renal Clear Cell Carcinoma.

Rodney E Shackelford, Jehan Abdulsattar, Eric X Wei, James Cotelingam, Domenico Coppola, Guillermo A Herrera

Open access · bronzeAbstract read
In one paragraph

Article in Anticancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 28 citations in OpenAlex.

  1. Significance of GSH and HRedox report : communications in free radical research · 2026
    Review
  2. Article
  3. Article
  4. Emerging roles of hydrogen sulfide-metabolizing enzymes in cancer.Redox report : communications in free radical research · 2024
    Review
  5. Cystathionine-The Journal of international medical research · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. The CBS-HBritish journal of cancer · 2022
    Article
  12. Article
  13. Molecular Functions of Hydrogen Sulfide in Cancer.Pathophysiology : the official journal of the International Society for Pathophysiology · 2021
    Review
  14. Hydrogen Sulfide and the Kidney.Advances in experimental medicine and biology · 2021
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rodney E ShackelfordDepartment of Pathology and Translational Pathobiology, LSU Health Shreveport, Shreveport, LA, U.S.A. rshack@lsuhsc.edu.
Jehan AbdulsattarDepartment of Pathology and Translational Pathobiology, LSU Health Shreveport, Shreveport, LA, U.S.A.
Eric X WeiDepartment of Pathology and Translational Pathobiology, LSU Health Shreveport, Shreveport, LA, U.S.A.
James CotelingamDepartment of Pathology and Translational Pathobiology, LSU Health Shreveport, Shreveport, LA, U.S.A.
Domenico CoppolaDepartment of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A.
Guillermo A HerreraDepartment of Pathology and Translational Pathobiology, LSU Health Shreveport, Shreveport, LA, U.S.A.
Moffitt Cancer Center · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
NCI NIH HHS P30 CA076292
6 · The paper itself

Abstract

backgroundRenal oncocytomas (ROs), and clear cell (RCC) and urothelial carcinomas (UC), are common renal neoplasms. Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step of NAD MATERIALS AND

methodsWe used tissue microarrays to examine Nampt and the H

resultsCompared to benign kidney, all three neoplasms showed increased Nampt and CBS protein levels, with the levels increasing in RCC at higher Fuhrman grades.

conclusionH

Indexed as

Adenoma, OxyphilicCarcinoma, Renal CellCystathionine beta-SynthaseCytokinesHumansHydrogen SulfideKidneyKidney NeoplasmsNicotinamide PhosphoribosyltransferaseCystathionine beta-SynthaseCytokinesHydrogen SulfideNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humancystathionine-β-synthaseFuhrman gradenicotinamide phosphoribosyltransferaseRenal cancer

Identifiers

PMID28668830
PMCPMC7771350
OpenAlexW2984175559

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.