Observational studyJournal of critical care2017
Clinical predictors of early death from sepsis.
Observational study in Journal of critical care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Trial
- Trial
- Metabolic profiles in community-acquired pneumonia: developing assessment tools for disease severity.Critical care (London, England) · 2018Trial
- Co-Evaluation of Lactate, Base Excess, and Albumin as Predictors of Mortality in Sepsis by Excluding the Factors That Affect Their Levels: An Observational Study.Biomedicines · 2025Article
- Hierarchical Capability in Distinguishing Severities of Sepsis via Serum Lactate: A Network Meta-Analysis.Biomedicines · 2024Review
- Association of Leukocyte Subpopulations Identified by Flow Cytometry with Outcomes of Sepsis in a Respiratory Intensive Care Unit: An Observational Study.Journal of intensive care medicine · 2024Observational
- Frequent temporal patterns of physiological and biological biomarkers and their evolution in sepsis.Artificial intelligence in medicine · 2023Article
- Septic shock definitions and associated outcomes in blood culture positive critically ill patients.Annals of translational medicine · 2023Article
- Determinants of Survival in obstetric Sepsis: Retrospective Observational Study.Journal of obstetrics and gynaecology of India · 2022Article
- Incidence and risk factors associated with early death in patients with emergency department septic shock.Acute and critical care · 2022Article
- Vasopressor Choice and Timing in Vasodilatory Shock.Critical care (London, England) · 2022Review
- Assessment of Metabolic Dysfunction in Sepsis in a Retrospective Single-Centre Cohort.Critical care research and practice · 2021Article
- Sequential Organ Failure Assessment Component Score Prediction of In-hospital Mortality From Sepsis.Journal of intensive care medicine · 2020Article
- Delta Lactate (Three-hour Lactate Minus Initial Lactate) Prediction of In-hospital Death in Sepsis Patients.Cureus · 2020Article
- Prevalence, potential risk factors and mortality rates of acute respiratory distress syndrome in Chinese patients with sepsis.The Journal of international medical research · 2020Article
- Emergency department non-invasive cardiac output study (EDNICO): an accuracy study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2020Observational
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposePatients with severe sepsis who experience rapid, early deterioration and death are of particular concern. Our objective was to identify predictors of early death in Emergency Department (ED) patients with severe sepsis.
methodsSecondary analysis of two prospective studies of adult ED patients with severe sepsis. The primary outcome was early death, defined as death within 24h of triage.
resultsOut of 410 severe sepsis admissions, 20 patients experienced early death. These patients demonstrated significantly higher initial lactate (7.3 versus 3.3mmol/L, p<0.001) and modified SOFA (mSOFA) scores (10 vs 6, p<0.001), were less likely to normalize their lactate (p<0.001), had lower initial pH (p<0.001), and more frequently had early positive blood cultures (p=0.021). Multivariable logistic regression identified initial serum lactate level (OR 1.19, 95% CI 1.06-1.35) and mSOFA score (OR 1.17, 95% CI 1.00-1.36) as independent predictors of early death. A repeat lactate≥5mmol/L had a sensitivity of 55% and specificity of 89% for early death. There were no significant treatment differences between groups.
conclusionInitial serum lactate and mSOFA score were independent predictors of mortality within 24h of ED admission in patients with severe sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.