Evidence map›Paper›PMID 28668648›Full record

ArticleEarly human development2017

Familial digit ratio (2D:4D) associations in a general population sample from Wales.

Gareth Richards, Wynford Bellin, William Davies

Abstract read
In one paragraph

Article in Early human development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Influence of gonadal steroids on cortical surface area in infancy.Cerebral cortex (New York, N.Y. : 1991) · 2022
    Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gareth RichardsAutism Research Centre, Department of Psychiatry, University of Cambridge, UK. Electronic address: gvr22@medschl.cam.ac.uk.
Wynford BellinSchool of Social Sciences, Cardiff University, UK.
William DaviesMRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences and Neuroscience and Mental Health Research Institute, Schools of Psychology and Medicine, Cardiff University, UK.

Funding

Medical Research Council MR/L010305/1
6 · The paper itself

Abstract

backgroundThe relative length of the second and fourth fingers (2D:4D) may be a sex-linked correlate of prenatal androgen exposure. However, the nature of the sex-linkage is controversial, with evidence for both X- and Y-linkage of the 2D:4D phenotype.

aimsTo examine transgenerational effects relating to sex-linkage. In addition, assortative mating on 2D:4D was considered, as well as associations between 2D:4D and age and sex. STUDY

designA family study was conducted. Parents and offspring completed a demographic questionnaire, and digit ratios were calculated from photocopies of participants' hands. SUBJECTS: We recruited and phenotyped 585 individuals attending a cultural festival in Wales. 2D:4D information was available for 47 mother-son dyads, 70 mother-daughter dyads, 31 father-son dyads and 30 father-daughter dyads. OUTCOME MEASURES: Correlations between 2D:4D of parents and children, as well as between mothers and fathers were conducted. 2D:4D was also examined in relation to age and sex. RESULTS AND

conclusionsThere was a sex difference in 2D:4D (males<females). Within the dyads, there was a significant positive correlation between mother and daughter 2D:4D, but no significant correlation between mother and son ratios, nor between father and offspring ratios. The overall pattern of correlations (with emphasis on father-son dyads) was not supportive of Y-linkage. There was a positive correlation between 2D:4D and age in children, and a negative correlation between 2D:4D and age in adults, and no evidence of assortative mating. Our data are consistent with the notion of 2D:4D as a sexually-dimorphic, mildly age-sensitive, and transgenerationally-transmitted trait that is more likely to be X- than Y-linked.

Indexed as

Genetic LinkagePedigreeAdolescentAdultAgedAged, 80 and overAge FactorsChildChromosomes, Human, XChromosomes, Human, YFemaleFingersHumansMaleMiddle AgedPhenotypeTestosterone2D:4DAssortative matingDigit ratioPrenatal testosteroneSex hormonesSex linkageTransgenerational effects

Identifiers

PMID28668648
PMCPMC5566275

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.