Evidence map›Paper›PMID 28668538›Full record

ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2018

Community Practice Implementation of a Self-administered Version of PREMM

Daniel G Luba, James A DiSario, Colleen Rock, Devki Saraiya, Kelsey Moyes, Krystal Brown, Kristen Rushton, Maydeen M Ogara, Mona Raphael, Dayna Zimmerman and 7 more

Open access · greenAbstract read
In one paragraph

Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Development and Validation of the PREMMplus Model for Multigene Hereditary Cancer Risk Assessment.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
    Article
  8. Who Should Have Multigene Germline Testing for Hereditary Cancer?Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
    Article
  9. Interventions to improve delivery of cancer genetics services in the United States: A scoping review.Genetics in medicine : official journal of the American College of Medical Genetics · 2022
    Article
  10. Article
  11. Review
  12. Recent advances in Lynch syndrome.Experimental hematology & oncology · 2021
    Review
  13. Diagnostics of Mutations in MMR/Diagnostics (Basel, Switzerland) · 2020
    Review
  14. Review
  15. Review
  16. Review
  17. Recent advances in Lynch syndrome.Familial cancer · 2019
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Daniel G LubaMonterey Bay GI Consultants Medical Group and Research Institute, Inc, Monterey, California.
James A DiSarioMonterey Bay GI Consultants Medical Group and Research Institute, Inc, Monterey, California.
Colleen RockMyriad Genetic Laboratories, Inc, Salt Lake City, Utah.
Devki SaraiyaMyriad Genetic Laboratories, Inc, Salt Lake City, Utah.
Kelsey MoyesMyriad Genetic Laboratories, Inc, Salt Lake City, Utah.
Krystal BrownMyriad Genetic Laboratories, Inc, Salt Lake City, Utah.
Kristen RushtonMyriad Genetic Laboratories, Inc, Salt Lake City, Utah.
Maydeen M OgaraMonterey Bay GI Consultants Medical Group and Research Institute, Inc, Monterey, California.
Mona RaphaelMonterey Bay GI Consultants Medical Group and Research Institute, Inc, Monterey, California.
Dayna ZimmermanMonterey Bay GI Consultants Medical Group and Research Institute, Inc, Monterey, California.
Kimmie GarridoMonterey Bay GI Consultants Medical Group and Research Institute, Inc, Monterey, California.
Evelyn SilgueroMonterey Bay GI Consultants Medical Group and Research Institute, Inc, Monterey, California.
Jonathan NelsonMyriad Genetic Laboratories, Inc, Salt Lake City, Utah.
Matthew B YurgelunDana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, Massachusetts.
Fay KastrinosColumbia University Medical Center, New York, New York.
Richard J WenstrupMyriad Genetic Laboratories, Inc, Salt Lake City, Utah.
Sapna SyngalDana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address: sapna_syngal@dfci.harvard.edu.
Myriad Genetics · USBrigham and Women's Hospital · USColumbia University Irving Medical Center · USDana-Farber Cancer Institute · US

Funding

Validation and extension of the PREMM Model for mismatch repair gene mutationsR01CA132829 · NCI · DANA-FARBER CANCER INST · PI SYNGAL, SAPNA · 2008 to 2022
$5.6M
Assessment of Inherited Colon Cancer Prediction Models in Diverse PopulationsK07CA151769 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KASTRINOS, FAY · 2010 to 2014
$855k
NCI NIH HHS K07 CA151769NCI NIH HHS R01 CA132829
6 · The paper itself

Abstract

BACKGROUND &

aimsLynch syndrome is a genetic disorder that greatly increases risk for colorectal and other cancers, although it is underdiagnosed. Prediction of MLH1, MSH2, and MSH6 (PREMM

methodsPREMM

resultsOf the 3134 individuals assessed by PREMM

conclusionsA patient self-administered version of the PREMM

Indexed as

AdolescentAdultAgedAged, 80 and overCaliforniaColorectal Neoplasms, Hereditary NonpolyposisFemaleFollow-Up StudiesHumansMaleMedical History TakingMiddle AgedProspective StudiesRisk AssessmentYoung AdultEndometrial CancerFamilial Colon CancerGeneticsProtocol Integration

Identifiers

PMID28668538
PMCPMC5734958
OpenAlexW2729961408

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.