Evidence map›Paper›PMID 28668388›Full record

ArticleBiochemical and biophysical research communications2017

AMPKα1 deficiency suppresses brown adipogenesis in favor of fibrogenesis during brown adipose tissue development.

Junxing Zhao, Qiyuan Yang, Lupei Zhang, Xingwei Liang, Xiaofei Sun, Bo Wang, Yanting Chen, Meijun Zhu, Min Du

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Junxing ZhaoDepartment of Animal Sciences and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030800, China; Department of Animal Sciences, Washington State University, Pullman, WA, 99164, USA.
Qiyuan YangDepartment of Animal Sciences, Washington State University, Pullman, WA, 99164, USA.
Lupei ZhangDepartment of Animal Sciences, Washington State University, Pullman, WA, 99164, USA; Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
Xingwei LiangDepartment of Animal Sciences, Washington State University, Pullman, WA, 99164, USA.
Xiaofei SunSchool of Food Science, Washington State University, Pullman, WA, 99164, USA.
Bo WangDepartment of Animal Sciences, Washington State University, Pullman, WA, 99164, USA.
Yanting ChenDepartment of Animal Sciences, Washington State University, Pullman, WA, 99164, USA.
Meijun ZhuSchool of Food Science, Washington State University, Pullman, WA, 99164, USA.
Min DuDepartment of Animal Sciences and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030800, China; Department of Animal Sciences, Washington State University, Pullman, WA, 99164, USA. Electronic address: min.du@wsu.edu.
Washington State University · USChinese Academy of Agricultural Sciences · CNShanxi Agricultural University · CN

Funding

Maternal obesity, AMPK and fetal brown adipogenesisR01HD067449 · NICHD · WASHINGTON STATE UNIVERSITY · PI MIN DU · 2010 to 2026
$4.6M
Zfp423 and Progenitor Adipogenesis during AgingR21AG049976 · NIA · WASHINGTON STATE UNIVERSITY · PI DU, MIN · 2016 to 2017
$405k
NIA NIH HHS R21 AG049976NICHD NIH HHS R01 HD067449
6 · The paper itself

Abstract

Brown adipose tissue (BAT) dissipates energy for thermogenesis which reduces or prevents obesity and metabolic dysfunction. AMP-activated protein kinase (AMPK) is a master regulator of energy metabolism and its activity is inhibited in the developing BAT due to obesity. We previously found that AMPK is required for brown fat development and thermogenic function, but the non-brown adipogenic differentiation of progenitor cells due to AMPKα1 deficiency has not been defined. We found that, in vivo, the thermogenic capacity and morphology of BAT were compromised due to AMPK deficiency, which was correlated with decreased progenitor density in BAT. In addition, the expression of fibrogenic markers was higher in AMPK deficient compared to wild-type mice. Furthermore, we transplanted AMPKα1 wild-type (WT) and floxed BAT into the same recipient mice; following tamoxifen induced AMPKα1 knockout in floxed BAT, the fibrogenesis was enhanced compared to WT mice. Taken together, our data demonstrated that AMPKα1 deficiency suppressed brown adipogenesis in favor of fibrogenesis during BAT development.

Indexed as

Adipocytes, BrownAdipogenesisAdipose Tissue, BrownAMP-Activated Protein KinasesAnimalsCell DifferentiationFibroblastsGene ExpressionMiceMice, TransgenicTamoxifenThermogenesisAMP-Activated Protein KinasesPrkaa1 protein, mouseTamoxifenAMPKα1Brown adipose tissueFibrogenesisProgenitor cellsThermogenesis

Identifiers

PMID28668388
PMCPMC5737707
OpenAlexW2725368921

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.