Evidence map›Paper›PMID 28668193›Full record

ArticleBioorganic & medicinal chemistry letters2017

Diaminopimelic acid (DAP) analogs bearing isoxazoline moiety as selective inhibitors against meso-diaminopimelate dehydrogenase (m-Ddh) from Porphyromonas gingivalis.

Hongguang Ma, Victoria N Stone, Huiqun Wang, Glen E Kellogg, Ping Xu, Yan Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hongguang MaDepartment of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA.
Victoria N StonePhilips Institute for Oral Health Research, Virginia Commonwealth University, 521 North 11th Street, Richmond, VA 23298, USA; Department of Microbiology and Immunology, Virginia Commonwealth University, 1101 East Marshall Street, Richmond, VA 23298, USA.
Huiqun WangDepartment of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA.
Glen E KelloggDepartment of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA; Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA.
Ping XuPhilips Institute for Oral Health Research, Virginia Commonwealth University, 521 North 11th Street, Richmond, VA 23298, USA; Department of Microbiology and Immunology, Virginia Commonwealth University, 1101 East Marshall Street, Richmond, VA 23298, USA.
Yan ZhangDepartment of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA. Electronic address: yzhang2@vcu.edu.

Funding

Interaction of Colonizer and Pathogen In Oral BiofilmR01DE023078 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI XU, PING · 2013 to 2017
$1.9M
NIDCR NIH HHS R01 DE023078
6 · The paper itself

Abstract

Two diastereomeric analogs (1 and 2) of diaminopimelic acid (DAP) bearing an isoxazoline moiety were synthesized and evaluated for their inhibitory activities against meso-diaminopimelate dehydrogenase (m-Ddh) from the periodontal pathogen, Porphyromonas gingivalis. Compound 2 showed promising inhibitory activity against m-Ddh with an IC

Indexed as

Amino Acid OxidoreductasesAnti-Bacterial AgentsDiaminopimelic AcidDose-Response Relationship, DrugEnzyme InhibitorsIsoxazolesMicrobial Sensitivity TestsModels, MolecularMolecular StructurePorphyromonas gingivalisStructure-Activity RelationshipAmino Acid OxidoreductasesAnti-Bacterial Agentsdiaminopimelate dehydrogenaseDiaminopimelic AcidEnzyme InhibitorsIsoxazolesAntibacterial activityDiaminopimelic acidmeso-Diaminopimelate dehydrogenase inhibitorMolecular modeling

Identifiers

PMID28668193
PMCPMC5546221

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.