SynthesisFertility and sterility2017
Reevaluating response and failure of medical treatment of endometriosis: a systematic review.
Synthesis in Fertility and sterility, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 130 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Hyivy Device as a Non-hormonal Therapy in People With Endometriosis
Risk Factors for Hormonal Therapy Failure in Patients With Endometriosis.
Glycemic Regulation as Endometriosis Adjunct Treatment
Who cites it
130 citing papers in PubMed, 10 syntheses or guidelines pooled it, 283 citations in OpenAlex.
- [Pain medicine aspects of the updated S2k guideline "Diagnosis and treatment of endometriosis"].Schmerz (Berlin, Germany) · 2026Guideline
- The effectiveness and safety of physical activity and exercise on women with endometriosis: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Questionnaires for the Assessment of Central Sensitization in Endometriosis: What Is the Available Evidence? A Systematic Review with a Narrative Synthesis.Reproductive sciences (Thousand Oaks, Calif.) · 2024Pooled it
- Effectiveness of psychological interventions in endometriosis: a systematic review with meta-analysis.Frontiers in psychology · 2024Pooled it
- Progestins in the symptomatic management of endometriosis: a meta-analysis on their effectiveness and safety.BMC women's health · 2022Pooled it
- Effectiveness of Dietary Interventions in the Treatment of Endometriosis: a Systematic Review.Reproductive sciences (Thousand Oaks, Calif.) · 2022Pooled it
- Is intracrinology of endometriosis relevant in clinical practice? A systematic review on estrogen metabolism.Frontiers in endocrinology · 2022Pooled it
- Selective oestrogen receptor modulators (SERMs) for endometriosis.The Cochrane database of systematic reviews · 2021Pooled it
- Clinical Utility of Presacral Neurectomy as an Adjunct to Conservative Endometriosis Surgery: Systematic Review and Meta-Analysis of Controlled Studies.Scientific reports · 2020Pooled it
- The role of catastrophizing in chronic cyclical pelvic pain: A systematic review and meta-analysis.Women's health (London, England)Pooled it
- Efficacy and Safety of Elagolix Versus Dienogest for Treatment of Moderate-to-Severe Endometriosis Pain: A Phase III, Multicentric, Double-Blind, Active-Controlled, Non-Inferiority Study.BJOG : an international journal of obstetrics and gynaecology · 2026Trial
- The Benefits of an Integral HAMMAM Experience Combining Hydrotherapy and Swedish Massage on Pain, Subjective Well-Being and Quality of Life in Women with Endometriosis-Related Chronic Pelvic Pain: A Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2024Trial
- Two-year efficacy and safety of relugolix combination therapy in women with endometriosis-associated pain: SPIRIT open-label extension study.Human reproduction (Oxford, England) · 2024Trial
- Simvastatin and Primaquine Identified as Potential Endometriosis Therapeutics via a Novel Epithelial-Stromal Assembloid Drug Screening Assay.bioRxiv : the preprint server for biology · 2026Article
- Extracellular matrix composition and stiffness regulates progesterone responsiveness and decidualization.iScience · 2026Article
- Article
- A framework for longitudinal health AI agents.Nature health · 2026Article
- Article
- Effectiveness of BMMSC and Dienogest on IL-1β, IL-8 Expression and Lesion Area in Endometriosis Mice.JBRA assisted reproduction · 2026Article
- Economic evaluation of a digital symptom checker for endometriosis using a Markov decision process model.NPJ digital medicine · 2026Article
70 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess patient response rates to medical therapies used to treat endometriosis-associated pain.
designA systematic review with the use of Medline and Embase.
settingNot applicable. PATIENT(S): Women receiving medical therapy to treat endometriosis. INTERVENTIONS(S): None. MAIN OUTCOME MEASURE(S): The proportions of patients who: experienced no reduction in endometriosis-associated pain symptoms; had pain symptoms remaining at the end of the treatment period; had pain recurrence after treatment cessation; experienced an increase or no change in disease score during the study; were satisfied with treatment; and discontinued therapy owing to adverse events or lack of efficacy. The change in pain symptom severity experienced during and after treatment, as measured on the visual analog scale, was also assessed. RESULT(S): In total, 58 articles describing 125 treatment arms met the inclusion criteria. Data for the response of endometriosis-associated pain symptoms to treatment were presented in only 29 articles. The median proportions of women with no reduction in pain were 11%-19%; at the end of treatment, 5%-59% had pain remaining; and after follow-up, 17%-34% had experienced recurrence of pain symptoms after treatment cessation. After median study durations of 2-24 months, the median discontinuation rates due to adverse events or lack of efficacy were 5%-16%. CONCLUSION(S): Few studies of medical therapies for endometriosis report outcomes that are relevant to patients, and many women gain only limited or intermittent benefit from treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.