Evidence map›Paper›PMID 28667908›Full record

ArticleRedox biology2017

Transcription factor NRF2 controls the fate of neural stem cells in the subgranular zone of the hippocampus.

Natalia Robledinos-Antón, Ana I Rojo, Elisabete Ferreiro, Ángel Núñez, Karl-Heinz Krause, Vincent Jaquet, Antonio Cuadrado

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 74 citations in OpenAlex.

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  16. Aging, NRF2, and TAU: A Perfect Match for Neurodegeneration?Antioxidants (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Natalia Robledinos-AntónInstituto de Investigaciones Biomédicas "Alberto Sols", Faculty of Medicine, Autonomous University of Madrid (UAM), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Ana I RojoInstituto de Investigaciones Biomédicas "Alberto Sols", Faculty of Medicine, Autonomous University of Madrid (UAM), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Elisabete FerreiroCenter for Neuroscience and Cell Biology, Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Portugal.
Ángel NúñezDepartment of Anatomy, Histology and Neuroscience, Autonomous University of Madrid, Madrid, Spain.
Karl-Heinz KrauseDepartment of Pathology and Immunology, University of Geneva Medical School, 1 rue Michel Servet, 1211 Geneva, Switzerland.
Vincent JaquetDepartment of Pathology and Immunology, University of Geneva Medical School, 1 rue Michel Servet, 1211 Geneva, Switzerland.
Antonio CuadradoInstituto de Investigaciones Biomédicas "Alberto Sols", Faculty of Medicine, Autonomous University of Madrid (UAM), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Electronic address: antonio.cuadrado@uam.es.
Instituto de Investigaciones Biomédicas Sols-Morreale · ESUniversity of Geneva · CHUniversidad Autónoma de Madrid · ESUniversity of Coimbra · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neural stem/progenitor cells (NSPCs) located at the subgranular zone (SGZ) of the hippocampus participate in the maintenance of synaptic networks that ensure cognitive functions during life. Although it is known that this neurogenic niche losses activity with oxidative stress and ageing, the molecular events involved in its regulation are largely unknown. Here, we studied the role of transcription factor Nuclear Factor-Erythroid 2-Related Factor 2 (NRF2) in the control of NSPCs destinies in the SGZ. We first describe that NRF2-knockout (Nrf2

Indexed as

NeurogenesisAnimalsAstrocytesHEK293 CellsHippocampusHumansLong-Term PotentiationMiceMice, Inbred C57BLNeural Stem CellsNeuronsOligodendrogliaAgingHippocampal neurogenesisNeural stem cellsNRF2Oxidative stressSubgranular zone

Identifiers

PMID28667908
PMCPMC5493838
OpenAlexW2731169161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.