Evidence map›Paper›PMID 28667452›Full record

ArticleJournal of endocrinological investigation2017

Role of contrast-enhanced ultrasound to define prognosis and predict response to biotherapy in pancreatic neuroendocrine tumors.

M Del Prete, A Di Sarno, R Modica, F Lassandro, A Giorgio, A Bianco, M Muto, M Gasperi, F Del Prete, A Colao and 3 more

Open access · bronzeAbstract read
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In one paragraph

Article in Journal of endocrinological investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Imaging of pancreatic hepatoid adenocarcinoma: a scoping review.Quantitative imaging in medicine and surgery · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Ultrasound diagnosis of pancreatic solid tumors.Journal of medical ultrasonics (2001) · 2020
    Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

M Del PreteDepartment of Clinical Medicine and Surgery, Federico II University, Naples, Italy. michidelpre@gmail.com.
A Di SarnoUOC of Oncology, A.O. dei Colli, Monaldi Unit, Naples, Italy.
R ModicaDepartment of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
F LassandroUOC of Radiology, A.O. dei Colli, Monaldi Unit, Naples, Italy.
A GiorgioInterventional Unit Ultrasound, A.O. dei Colli, D. Cotugno Unit, Naples, Italy.
A BiancoUOC of Oncology, A.O. dei Colli, Monaldi Unit, Naples, Italy.
M MutoInterventional Unit Ultrasound, A.O. dei Colli, D. Cotugno Unit, Naples, Italy.
M GasperiDepartment of Medicine and Health Sciences, Section of Endocrinology, University of Molise, Campobasso, Italy.
F Del PreteCentre for Economic and International Studies, University of Rome "Tor Vergata", Rome, Italy.
A ColaoDepartment of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
V MontesarchioUOC of Oncology, A.O. dei Colli, Monaldi Unit, Naples, Italy.
A FaggianoThyroid and Parathyroid Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione G. Pascale"-IRCCS, Naples, Italy.
ENETS Centre of Excellence Multidisciplinary Group for Neuroendocrine Tumors in Naples (Italy)
Ospedale Monaldi · ITFederico II University Hospital · ITOspedale D. Cotugno · ITIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITUniversity of Molise · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe incidence of neuroendocrine tumors (NETs) is progressively increasing. Most cases arise from the digestive system, where ileum, rectum and pancreas represent the commonest site of origin. Liver metastases are frequently detected at diagnosis or during the follow-up. Contrast-enhanced ultrasound (CEUS) is used in patients with pancreatic NETs (P-NETs) and liver metastases from P-NET but its role has not been standardized. The aim of this retrospective study was to investigate CEUS in patients with P-NETs and liver metastases from P-NET both as prognostic factor and predictor of response to therapy with somatostatin analogues (SSAs).

methodsCEUS was performed at the diagnosis of NET and 3, 6 and 12 months after the beginning of SSAs. CEUS pattern was compared with contrast-enhanced computed tomography (CT) pattern.

resultsThere was a significant association between CEUS and CT pattern (X

conclusionsIn patients with P-NET, CEUS pattern correlates with tumor grading, being homogeneous in G1-G2 but not in G3 tumors. After therapy with SSAs, CEUS is predictive of response to SSAs. These findings seem to support a role of CEUS as prognostic and predictive factor of response.

Indexed as

Biological TherapyContrast MediaAdultAgedFemaleFollow-Up StudiesHuman Growth HormoneHumansLiver NeoplasmsLymphatic MetastasisMaleMiddle AgedNeuroendocrine TumorsPancreatic NeoplasmsPrognosisRetrospective StudiesContrast MediaHuman Growth HormoneCEUSNeuroendocrine tumorsPrediction of responsePrognosisSomatostatin analogues

Identifiers

PMID28667452
OpenAlexW2728924804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.