ArticleScientific reports2017
Quantitative Proteomics Analysis of Plasmodium vivax Induced Alterations in Human Serum during the Acute and Convalescent Phases of Infection.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 21 citations in OpenAlex.
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- Challenges and Opportunities in Clinical Diagnostic Routine of Envenomation Using Blood Plasma Proteomics.Toxins · 2023Review
- Serum proteomic profile of wild stump-tailed macaques (Macaca arctoides) infected with malaria parasites in Thailand.PloS one · 2023Article
- A comprehensive rhythmicity analysis of host proteins and immune factors involved in malaria pathogenesis to decipher the importance of host circadian clock in malaria.Frontiers in immunology · 2023Article
- Elevated plasma α1-antichymotrypsin is a biomarker candidate for malaria patients.BMB reports · 2022Article
- Uncomplicated Plasmodium vivax malaria: mapping the proteome from circulating platelets.Clinical proteomics · 2022Article
- Multi-Omics Advancements towardsDiagnostics (Basel, Switzerland) · 2021Review
- Multiplexed quantitative proteomics provides mechanistic cues for malaria severity and complexity.Communications biology · 2020Article
- An Integrated Quantitative Proteomics Workflow for Cancer Biomarker Discovery and Validation in Plasma.Frontiers in oncology · 2020Article
- PvP01-DB: computational structural and functional characterization of soluble proteome of PvP01 strain of Plasmodium vivax.Database : the journal of biological databases and curation · 2020Article
- Malaria in India: The Need for New Targets for Diagnosis and Detection of Plasmodium vivax.Proteomics. Clinical applications · 2018Review
- Serum proteomic analysis of the anti‑arthritic effects of sinomenine on rats with collagen‑induced arthritis.Molecular medicine reports · 2018Article
- Characterization ofFrontiers in microbiology · 2018Article
- Review
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The radial distribution of Plasmodium vivax malaria burden has evoked enormous concern among the global research community. In this study, we have investigated the serum proteome alterations in non-severe vivax malaria patients before and during patient recuperation starting from the early febrile to the defervescence and convalescent stages of the infection. We have also performed an extensive quantitative proteomics analysis to compare the serum proteome profiles of vivax malaria patients with low (LPVM) and moderately-high (MPVM) parasitemia with healthy community controls. Interestingly, some of the serum proteins such as Serum amyloid A, Apolipoprotein A1, C-reactive protein, Titin and Haptoglobin, were found to be sequentially altered with respect to increased parasite counts. Analysis of a longitudinal cohort of malaria patients indicated reversible alterations in serum levels of some proteins such as Haptoglobin, Apolipoprotein E, Apolipoprotein A1, Carbonic anhydrase 1, and Hemoglobin subunit alpha upon treatment; however, the levels of a few other proteins did not return to the baseline even during the convalescent phase of the infection. Here we present the first comprehensive serum proteomics analysis of vivax malaria patients with different levels of parasitemia and during the acute and convalescent phases of the infection.
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