ArticleScientific reports2017
Transcriptome analysis explores genes related to shikonin biosynthesis in Lithospermeae plants and provides insights into Boraginales' evolutionary history.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Characterization of two G-type half-size ABC transporter genes from the lipid-secreting medicinal plant Lithospermum erythrorhizon.Journal of plant research · 2025Article
- Genome-Wide Comparison and Functional Characterization ofInternational journal of molecular sciences · 2023Article
- Promising Nanomedicines of Shikonin for Cancer Therapy.International journal of nanomedicine · 2023Review
- Arbuscular mycorrhizal fungi impact the production of alkannin/shikonin and their derivatives inFrontiers in microbiology · 2023Article
- Network Pharmacology Revealed the Mechanisms of Action ofClinical, cosmetic and investigational dermatology · 2023Article
- Differential microbial assemblages associated with shikonin-producing Borage species in two distinct soil types.Scientific reports · 2021Article
- Establishment of the hairy root culture of3 Biotech · 2020Article
- Two BAHD Acyltransferases Catalyze the Last Step in the Shikonin/Alkannin Biosynthetic Pathway.Plant physiology · 2020Article
- Dissection for Floral Micromorphology and Plastid Genome of Valuable Medicinal Borages Arnebia and Lithospermum (Boraginaceae).Frontiers in plant science · 2020Article
- Hybrid de novo genome assembly of red gromwell (Horticulture research · 2020Article
- CYP76B74 Catalyzes the 3''-Hydroxylation of Geranylhydroquinone in Shikonin Biosynthesis.Plant physiology · 2019Article
- Systematic analysis of DEMETER-like DNA glycosylase genes shows lineage-specific Smi-miR7972 involved in SmDML1 regulation in Salvia miltiorrhiza.Scientific reports · 2018Article
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9 authors.
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Abstract
Shikonin and its derivatives extracted from Lithospermeae plants' red roots have current applications in food and pharmaceutical industries. Previous studies have cloned some genes related to shikonin biosynthesis. However, most genes related to shikonin biosynthesis remain unclear, because the lack of the genome/transcriptome of the Lithospermeae plants. Therefore, in order to provide a new understanding of shikonin biosynthesis, we obtained transcriptome data and unigenes expression profiles in three shikonin-producing Lithospermeae plants, i.e., Lithospermum erythrorhizon, Arnebia euchroma and Echium plantagineum. As a result, two unigenes (i.e., G10H and 12OPR) that are involved in "shikonin downstream biosynthesis" and "methyl jasmonate biosynthesis" were deemed to relate to shikonin biosynthesis in this study. Furthermore, we conducted a Lamiids phylogenetic model and identified orthologous unigenes under positive selection in above three Lithospermeae plants. The results indicated Boraginales was more relative to Solanales/Gentianales than to Lamiales.
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