ArticleScientific reports2017
The Hippo pathway acts downstream of the Hedgehog signaling to regulate follicle stem cell maintenance in the Drosophila ovary.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Article
- Conserved cellular signals and mechanisms accompany the reproductive shutdown of honey bee (Apis mellifera) queens for dispersal.Communications biology · 2026Article
- Hh and EGFR-Ras signaling promote distinct steps of tumor progression in the Drosophila follicle epithelium.Nature communications · 2026Article
- Starve-Feed Cycles Direct Quiescence to Proliferation Transitions inbioRxiv : the preprint server for biology · 2026Article
- Independent signaling pathways provide a fail-safe mechanism to prevent tumorigenesis.bioRxiv : the preprint server for biology · 2025Article
- Regulation of somatic stem cell and niche precursor fates and proliferation of by Wnt, JAK-STAT, Hedgehog and Hippo/Yorkie pathways during Drosophila pupal ovary development resembles the signaling framework organizing adult stem cell behavior.bioRxiv : the preprint server for biology · 2025Article
- Bio-characteristics, tissue expression of miR-375 in hypothalamic-pituitary-ovarian axis and its regulation in reproduction-related diseases.Scientific reports · 2024Article
- Article
- Characterization and Comparative Analysis of Whole-Transcriptome Sequencing in High- and Low-Fecundity Chongming White Goat Ovaries during the Estrus Phase.Animals : an open access journal from MDPI · 2024Article
- SUMOylation of Bonus, theeLife · 2023Article
- Article
- Article
- Sas-Ptp10D shapes germ-line stem cell niche by facilitating JNK-mediated apoptosis.PLoS genetics · 2023Article
- Sequential events during the quiescence to proliferation transition establish patterns of follicle cell differentiation in the Drosophila ovary.Biology open · 2023Article
- Hippo Signaling in the Ovary: Emerging Roles in Development, Fertility, and Disease.Endocrine reviews · 2022Review
- HP1a-mediated heterochromatin formation inhibits high dietary sugar-induced tumor progression.Cell death & disease · 2021Article
- Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review).Molecular medicine reports · 2021Review
- Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis.Oncogene · 2020Article
- Signal transduction in the early Drosophila follicle stem cell lineage.Current opinion in insect science · 2020Review
- The HIPPO pathway in gynecological malignancies.American journal of cancer research · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Hippo pathway is conserved and plays important roles in organ size control. The core components of the Hippo pathway are two kinases Hippo (Hpo), Warts (Wts), and a transcription-co-activator Yorkie (Yki). Yki activity is regulated by phosphorylation, which affects its nuclear localization and stability. To determine the role of the Hippo pathway in stem cells, we examine follicle stem cells (FSCs) in the Drosophila ovary. Yki is detected in the nucleus of FSCs. Knockdown of yki in the follicle cell lineage leads to a disruption of the follicular epithelium. Mitotic clones of FSCs mutant for hpo or wts are maintained in the niche and tend to replace the other FSCs, and FSCs mutant for yki are rapidly lost, demonstrating that the Hippo pathway is both required and sufficient for FSC maintenance. Using genetic interaction analyses, we demonstrate that the Hedgehog pathway acts upstream of the Hippo pathway in regulating FSC maintenance. The nuclear localization of Yki is enhanced when the Hedgehog signaling is activated. Furthermore, a constitutively active but not a wild-type Yki promotes FSC maintenance as activation of the Hedgehog signaling does, suggesting that the Hedgehog pathway regulates Yki through a post-translational mechanism in maintaining FSCs.
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