Evidence map›Paper›PMID 28667229›Full record

ArticleBMJ open2017

Corticosteroids in sepsis: an updated systematic review and meta-analysis (protocol).

Bram Rochwerg, Simon Oczkowski, Reed Alexander Siemieniuk, Kusum Menon, Wojciech Szczeklik, Shane English, Thomas Agoritsas, Emilie Belley-Cote, Frédérick D'Aragon, Waleed Alhazzani and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Guideline
  2. Review
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  7. FulminantIDCases · 2020
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 7 countries.

Bram RochwergDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Simon OczkowskiDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Reed Alexander SiemieniukDepartment of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.
Kusum MenonDepartment of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada.
Wojciech SzczeklikDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Shane EnglishDepartment of Medicine (Critical Care), University of Ottawa, Ottawa, Ontario, Canada.
Thomas AgoritsasDepartment of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.
Emilie Belley-CoteDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Frédérick D'AragonCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke et Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Waleed AlhazzaniDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Erick DuanDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Kira Gossack-KeenanDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Jon SevranskyDivision of Pulmonary, Allergy and Critical Care, Department of Medicine, Emory University, Atlanta, Georgia, USA.
Per VandvikDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Bala VenkateshDepartment of Intensive Care, Wesley Hospital and Princess Alexandra Hospital, University of Queensland, St Lucia, Australia.
Gordon GuyattUniversity of Sydney, Sydney, Australia.
Djillali AnnaneDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
McMaster University · CAImpact · CACentre Hospitalier Universitaire de Sherbrooke · CAEmory University · USHôpital Raymond-Poincaré · FRJagiellonian University · PLOttawa Hospital · CAThe University of Queensland · AUThe University of Sydney · AUUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSepsis is associated with a dysregulated host response to infection and impaired endogenous corticosteroid metabolism. As such, therapeutic use of exogenous corticosteroids is a promising adjunctive intervention. Despite a large number of trials examining this research question, uncertainty persists regarding the effect of corticosteroids on survival in sepsis. Several large randomised controlled trials have been published recently prompting a re-evaluation of the available literature. METHODS AND ANALYSIS: A rigorous and reproducible search and screening process from a Cochrane review on the same topic was comprehensive to October 2014. We will search MEDLINE, EMBASE, LILACS, the Cochrane trial registry and clinicaltrials.gov for eligible randomised controlled trials investigating the use of corticosteroids in patients with sepsis from September 2014. Outcomes have been chosen by a semi-independent guideline panel, created in the context of a parallel ETHICS AND DISSEMINATION: The aim of this systematic review is to summarise the updated evidence on the efficacy and safety of corticosteroids in patients with sepsis. TRIAL REGISTRATION NUMBER: CRD42017058537.

Indexed as

Adrenal Cortex HormonesHumansLength of StayMeta-Analysis as TopicOrgan Dysfunction ScoresQuality of LifeRandomized Controlled Trials as TopicResearch DesignSepsisSystematic Reviews as TopicTreatment OutcomeAdrenal Cortex Hormonescorticosteroidsintensive caremeta-analysisSepsisshocksystematic review

Identifiers

PMID28667229
PMCPMC5726130
OpenAlexW2734878290

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.