Evidence map›Paper›PMID 28667172›Full record

ArticleThe Journal of biological chemistry2017

A haplotype variant of the human chromogranin A gene (

Lakshmi Subramanian, Abrar A Khan, Prasanna K R Allu, Malapaka Kiranmayi, Bhavani S Sahu, Saurabh Sharma, Madhu Khullar, Ajit S Mullasari, Nitish R Mahapatra

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PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Lakshmi SubramanianFrom the Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036.
Abrar A KhanFrom the Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036.
Prasanna K R AlluFrom the Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036.
Malapaka KiranmayiFrom the Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036.
Bhavani S SahuFrom the Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036.
Saurabh SharmaDepartment of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
Madhu KhullarDepartment of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
Ajit S MullasariInstitute of Cardiovascular Diseases, Madras Medical Mission, Chennai 600037.
Nitish R MahapatraFrom the Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036. Electronic address: nmahapatra@iitm.ac.in.
Indian Institute of Technology Madras · INPost Graduate Institute of Medical Education and Research · INMadras Medical Mission · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The acidic glycoprotein chromogranin A (CHGA) is co-stored/co-secreted with catecholamines and crucial for secretory vesicle biogenesis in neuronal/neuroendocrine cells. CHGA is dysregulated in several cardiovascular diseases, but the underlying mechanisms are not well established. Here, we sought to identify common polymorphisms in the

Indexed as

Gene Expression RegulationPolymorphism, Single NucleotidePromoter Regions, GeneticAllelesCardiovascular DiseasesCell Line, TumorChromatin ImmunoprecipitationChromogranin AComputational BiologyElectrophoretic Mobility Shift AssayGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGlucose Metabolism DisordersHumansIndiaCHGA protein, humanChromogranin AProto-Oncogene Proteins c-relRecombinant ProteinsREL protein, humancardiovascularchromograninc-Relhaplotypehypoxiainflammationmetabolic diseasesingle nucleotide polymorphismstranscriptiontranscriptional regulation

Identifiers

PMID28667172
PMCPMC5572921
OpenAlexW2729651715

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.