Evidence map›Paper›PMID 28667117›Full record

ArticleApplied and environmental microbiology2017

Reduced Mutation Rate and Increased Transformability of Transposon-Free Acinetobacter baylyi ADP1-ISx.

Gabriel A Suárez, Brian A Renda, Aurko Dasgupta, Jeffrey E Barrick

Open access · bronzeAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Bacteria as living biosensors for DNA.Nature reviews bioengineering · 2026
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  3. Review
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  5. Review
  6. Genome evolution ofApplied and environmental microbiology · 2025
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  7. Article
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  10. Article
  11. Article
  12. Article
  13. Genome reduction inFrontiers in bioengineering and biotechnology · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Design patterns for engineering genetic stability.Current opinion in biomedical engineering · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Gabriel A SuárezDepartment of Molecular Biosciences, Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, Texas, USA.
Brian A RendaDepartment of Molecular Biosciences, Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, Texas, USA.
Aurko DasguptaDepartment of Molecular Biosciences, Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, Texas, USA.
Jeffrey E BarrickDepartment of Molecular Biosciences, Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, Texas, USA jbarrick@cm.utexas.edu.ORCID http://orcid.org/0000-0003-0888-7358
The University of Texas at Austin · US

Funding

Identifying Mutations that Promote Microbial EvolvabilityR00GM087550 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI BARRICK, JEFFREY EVAN · 2011 to 2013
$724k
NIGMS NIH HHS R00 GM087550
6 · The paper itself

Abstract

The genomes of most bacteria contain mobile DNA elements that can contribute to undesirable genetic instability in engineered cells. In particular, transposable insertion sequence (IS) elements can rapidly inactivate genes that are important for a designed function. We deleted all six copies of IS

Indexed as

DNA Transposable ElementsAcinetobacterBacterial ProteinsGenome, BacterialMutation RatePoint MutationBacterial ProteinsDNA Transposable Elementsclean genomegenome engineeringinsertion sequencemutation accumulationsynthetic biology

Identifiers

PMID28667117
PMCPMC5561288
OpenAlexW2725169667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.