ArticleBioscience reports2017
Expression and prognostic value of HER-2/neu in primary breast cancer with sentinel lymph node metastasis.
Article in Bioscience reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Predictors of sentinel lymph node metastasis in cT1-2 cN0 breast cancer: A retrospective cohort study.Medicine · 2026Article
- Clinicopathological Characteristics of Breast Cancer Patients with Equivocal Immunohistochemistry: A Prevalence-Based Statistical Analysis.Iranian journal of pathology · 2025Article
- Tumor enhancement and shrinkage pattern in dynamic contrast-enhanced magnetic resonance imaging for predicting pathologic complete response after human epidermal growth factor receptor 2 (HER2)-targeted therapy in breast cancer.Quantitative imaging in medicine and surgery · 2024Article
- Factors Predictive of Positive Lymph Nodes for Breast Cancer.Current oncology (Toronto, Ont.) · 2023Article
- Factors Influencing Lymph Node Positivity in HER2/neu+ Breast Cancer Patients.Current oncology (Toronto, Ont.) · 2023Article
- Prognostic and predictive biomarkers for response to neoadjuvant chemoradiation in esophageal adenocarcinoma.Biomarker research · 2022Article
- A preoperative nomogram for predicting the risk of sentinel lymph node metastasis in patients with T1-2N0 breast cancer.Japanese journal of radiology · 2022Article
- Metastasis patterns and prognosis of octogenarians with metastatic breast cancer: A large-cohort retrospective study.PloS one · 2022Article
- Prediction of lymph node metastasis in patients with breast invasive micropapillary carcinoma based on machine learning and SHapley Additive exPlanations framework.Frontiers in oncology · 2022Article
- Metabolomics research on potential role for 9-cis-retinoic acid in breast cancer progression.Cancer science · 2018Article
- Significance and prognostic role of human epidermal growth factor receptor 2 and RAB1A expression in gastric cancer.Oncology letters · 2018Article
- The development of CAR design for tumor CAR-T cell therapy.Oncotarget · 2018Review
- Clinical risk analysis of non-visualized sentinel lymph node in breast cancer.Cancer biomarkers : section A of Disease markers · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study explores the correlation of human epidermal growth factor receptor-2 (HER-2) protein expression with sentinel lymph node (SLN) metastasis and prognosis of breast cancer. The breast cancer tissues and adjacent tissues were obtained from patients with primary breast cancer. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to detect the mRNA level of HER-2. Spearman correlation analysis was used to analyze the correlation of HER-2 expression with SLN metastasis. The disease-free survival (DFS) and overall survival (OS) of breast cancer patients were investigated. Univariate and multivariate analyses were performed to explore factors influencing SLN metastasis and prognosis of breast cancer. Compared with adjacent tissues, HER-2 expression was significantly up-regulated in breast cancer tissues. HER-2 expression was correlated with the pathological type, tumor node metastasis (TNM) staging, histological grade, blood vessel invasion, SLN metastasis, estrogen receptor (ER), and progesterone receptor (PR). The expression level of HER-2 was positively related to the SLN metastasis (
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