ArticleBone2017
Non-destructive NIR spectral imaging assessment of bone water: Comparison to MRI measurements.
Article in Bone, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Shedding Light on the Past: Temporal Classification of Zoological Specimens from Museum Collections with Portable NIR Sensors and Multivariate Error Modeling.Analytical chemistry · 2026Article
- Magnetic Resonance Imaging-Based Cohesive Extended Finite Element Modeling of Atypical Femoral Fracture.Journal of biomechanical engineering · 2026Article
- Prediction of biomechanical properties of ex vivo human femoral cortical bone using Raman spectroscopy and machine learning algorithms.Bone reports · 2025Article
- The Multifactorial Relationship Between Bone Tissue Water and Stiffness at the Proximal Femur.Calcified tissue international · 2025Article
- Article
- Transmission-Based Vertebrae Strength Probe Development: Far Field Probe Property Extraction and Integrated Machine Vision Distance Validation Experiments.Sensors (Basel, Switzerland) · 2023Article
- Bone hydration: How we can evaluate it, what can it tell us, and is it an effective therapeutic target?Bone reports · 2022Article
- 3D UTE bicomponent imaging of cortical bone using a soft-hard composite pulse for excitation.Magnetic resonance in medicine · 2021Article
- Applications of Vibrational Spectroscopy for Analysis of Connective Tissues.Molecules (Basel, Switzerland) · 2021Review
- Characterization of connective tissues using near-infrared spectroscopy and imaging.Nature protocols · 2021Article
- Near infrared spectroscopic assessment of loosely and tightly bound cortical bone water.The Analyst · 2020Article
- Approaches forTissue engineering. Part C, Methods · 2020Article
- MRI-derived bone porosity index correlates to bone composition and mechanical stiffness.Bone reports · 2019Article
- Changing landscape of optical imaging in skeletal metastases.Journal of bone oncology · 2019Review
- Environmentally-Controlled Near Infrared Spectroscopic Imaging of Bone Water.Scientific reports · 2019Article
- Spatial correlation of native and engineered cartilage components at micron resolution.Annals of the New York Academy of Sciences · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Bone fracture risk increases with age, disease states, and with use of certain therapeutics, such as acid-suppressive drugs, steroids and high-dose bisphosphonates. Historically, investigations into factors that underlie bone fracture risk have focused on evaluation of bone mineral density (BMD). However, numerous studies have pointed to factors other than BMD that contribute to fragility, including changes in bone collagen and water. The goal of this study is to investigate the feasibility of using near infrared spectral imaging (NIRSI) to determine the spatial distribution and relative amount of water and organic components in whole cross-sections of bone, and to compare those results to those obtained using magnetic resonance imaging (MRI) methods. Cadaver human whole-section tibiae samples harvested from 18 donors of ages 27-97years underwent NIRSI and ultrashort echo time (UTE) MRI. As NIRSI data is comprised of broad absorbances, second derivative processing was evaluated as a means to narrow peaks and obtain compositional information. The (inverted) second derivative peak heights of the NIRSI absorbances correlated significantly with the mean peak integration of the water, collagen and fat NIR absorbances, respectively, indicating that either processing method could be used for compositional assessment. The 5797cm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.