Evidence map›Paper›PMID 28666970›Full record

ArticleBone2017

Relationships among ultrasonic and mechanical properties of cancellous bone in human calcaneus in vitro.

Keith A Wear, Srinidhi Nagaraja, Maureen L Dreher, Saghi Sadoughi, Shan Zhu, Tony M Keaveny

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 36 citations in OpenAlex.

  1. Observational
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Scattering in Cancellous Bone.Advances in experimental medicine and biology · 2022
    Article
  8. Mechanisms of Interaction of Ultrasound With Cancellous Bone: A Review.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Keith A WearU.S. Food and Drug Administration, Center for Devices and Radiological Health, 10903 New Hampshire Blvd., Silver Spring, MD 20993, USA. Electronic address: keith.wear@fda.hhs.gov.
Srinidhi NagarajaU.S. Food and Drug Administration, Center for Devices and Radiological Health, 10903 New Hampshire Blvd., Silver Spring, MD 20993, USA. Electronic address: Srinidhi.Nagaraja@fda.hhs.gov.
Maureen L DreherU.S. Food and Drug Administration, Center for Devices and Radiological Health, 10903 New Hampshire Blvd., Silver Spring, MD 20993, USA. Electronic address: Maureen.Dreher@fda.hhs.gov.
Saghi SadoughiOrthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, 5124 Etcheverry Hall, Mailstop 1740, University of California at Berkeley, Berkeley, CA 94720-1740, USA. Electronic address: ssadoughi@berkeley.edu.
Shan ZhuOrthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, 5124 Etcheverry Hall, Mailstop 1740, University of California at Berkeley, Berkeley, CA 94720-1740, USA. Electronic address: chloe_zhu@berkeley.edu.
Tony M KeavenyOrthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, 5124 Etcheverry Hall, Mailstop 1740, University of California at Berkeley, Berkeley, CA 94720-1740, USA; Department of Bioengineering, University of California, Berkeley, CA, USA. Electronic address: tonykeaveny@berkeley.edu.
United States Food and Drug Administration · USUniversity of California, Berkeley · US

Funding

Intramural FDA HHS FD999999
6 · The paper itself

Abstract

Clinical bone sonometers applied at the calcaneus measure broadband ultrasound attenuation and speed of sound. However, the relation of ultrasound measurements to bone strength is not well-characterized. Addressing this issue, we assessed the extent to which ultrasonic measurements convey in vitro mechanical properties in 25 human calcaneal cancellous bone specimens (approximately 2×4×2cm). Normalized broadband ultrasound attenuation, speed of sound, and broadband ultrasound backscatter were measured with 500kHz transducers. To assess mechanical properties, non-linear finite element analysis, based on micro-computed tomography images (34-micron cubic voxel), was used to estimate apparent elastic modulus, overall specimen stiffness, and apparent yield stress, with models typically having approximately 25-30 million elements. We found that ultrasound parameters were correlated with mechanical properties with R=0.70-0.82 (p<0.001). Multiple regression analysis indicated that ultrasound measurements provide additional information regarding mechanical properties beyond that provided by bone quantity alone (p≤0.05). Adding ultrasound variables to linear regression models based on bone quantity improved adjusted squared correlation coefficients from 0.65 to 0.77 (stiffness), 0.76 to 0.81 (apparent modulus), and 0.67 to 0.73 (yield stress). These results indicate that ultrasound can provide complementary (to bone quantity) information regarding mechanical behavior of cancellous bone.

Indexed as

CalcaneusCancellous BoneFinite Element AnalysisHumansStress, MechanicalUltrasonographyX-Ray MicrotomographyBone strengthCalcaneusCancellousFinite element analysisMechanicalMicro-CTUltrasound

Identifiers

PMID28666970
PMCPMC6941483
OpenAlexW2729783211

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.