Evidence map›Paper›PMID 28666722›Full record

ArticleUrologic oncology2017

Adjuvant pelvic radiation is associated with improved survival and decreased disease recurrence in pelvic node-positive penile cancer after lymph node dissection: A multi-institutional study.

Dominic H Tang, Rosa Djajadiningrat, Gregory Diorio, Juan Chipollini, Zhenjun Ma, Braydon J Schaible, Mario Catanzaro, Dingwei Ye, Yao Zhu, Nicola Nicolai and 3 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Urologic oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Outcomes of Adjuvant Radiation Therapy in Penile Cancer.Advances in radiation oncology · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Impact of radiation therapy on perineal urethrostomy for penile cancer.Clinical and translational radiation oncology · 2021
    Article
  12. Article
  13. Penile cancer: a Brazilian consensus statement for low- and middle-income countries.Journal of cancer research and clinical oncology · 2020
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Intrinsic radiosensitivity, genomic-based radiation dose and patterns of failure of penile cancer in response to adjuvant radiation therapy.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Dominic H TangDepartment of Urology, Moffitt Cancer Center, Tampa, FL. Electronic address: dominic.tang@moffitt.org.
Rosa DjajadiningratDepartment of Urology, Antoni van Leeuwenhoek Hospital, Netherlands Cancer Institute, Amsterdam, Netherlands.
Gregory DiorioDepartment of Urology, Moffitt Cancer Center, Tampa, FL.
Juan ChipolliniDepartment of Urology, Moffitt Cancer Center, Tampa, FL.
Zhenjun MaDepartment of Bioinformatics and Biostatistics, Moffitt Cancer Center, Tampa, FL.
Braydon J SchaibleDepartment of Bioinformatics and Biostatistics, Moffitt Cancer Center, Tampa, FL.
Mario CatanzaroDepartment of Urology, Fondazione IRCCS IstitutoNazionaleTumori, Milano, Italy.
Dingwei YeDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
Yao ZhuDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
Nicola NicolaiDepartment of Urology, Fondazione IRCCS IstitutoNazionaleTumori, Milano, Italy.
Simon HorenblasDepartment of Urology, Antoni van Leeuwenhoek Hospital, Netherlands Cancer Institute, Amsterdam, Netherlands.
Peter A S JohnstoneDepartment of Radiation Oncology, Moffitt Cancer Center, Tampa, FL.
Philippe E SpiessDepartment of Urology, Moffitt Cancer Center, Tampa, FL.
Moffitt Cancer Center · USFondazione IRCCS Istituto Nazionale dei Tumori · ITFudan University Shanghai Cancer Center · CNThe Netherlands Cancer Institute · NL

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
NCI NIH HHS P30 CA076292
6 · The paper itself

Abstract

purposeFew studies have examined the role of radiation therapy in advanced penile squamous cell carcinoma. We sought to evaluate the association of adjuvant pelvic radiation with survival and recurrence for patients with penile cancer and positive pelvic lymph nodes (PLNs) after lymph node dissection. MATERIALS AND

methodsData were collected retrospectively across 4 international centers of patients with penile squamous cell carcinoma undergoing lymph node dissections from 1980 to 2013. Further, 92 patients with available adjuvant pelvic radiation status and positive PLNs were analyzed. Disease-specific survival (DSS) and recurrence were analyzed using the Kaplan-Meier method and multivariable Cox proportional hazards model.

results43% (n = 40) of patients received adjuvant pelvic radiation after a positive PLN dissection. Median follow-up was 9.3 months (interquartile range: 5.2-19.8). Patients receiving adjuvant pelvic radiation had a median DSS of 14.4 months vs. 8 months in the nonradiation group, respectively (P = 0.023). Patients without adjuvant pelvic radiation were associated with worse overall survival (hazard ratio [HR] = 1.7; 95% CI: 1.01-2.92; P = 0.04) and DSS (HR = 1.9; 95% CI: 1.09-3.36; P = 0.02) on multivariable analysis. Median time to recurrence was 7.7 months vs. 5.3 months in the radiation and nonradiation arm, respectively (P = 0.042). Patients without adjuvant pelvic radiation was also independently associated with higher overall recurrence on multivariable analysis (HR = 1.8; 95% CI: 1.06-3.12; P = 0.03).

conclusionsAdjuvant pelvic radiation is associated with improved survival and decreased recurrence in this population of patients with penile cancer with positive PLNs.

Indexed as

AgedHumansLymph Node ExcisionMaleMiddle AgedNeoplasm Recurrence, LocalPelvisPenile NeoplasmsRadiotherapy, AdjuvantRetrospective StudiesSurvival AnalysisAdjuvant radiationLymph node dissectionPenile cancerRecurrenceSurvival

Identifiers

PMID28666722
PMCPMC7771352
OpenAlexW2731625696

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.