ArticleEpidemics2017
A human time dose response model for Q fever.
Article in Epidemics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Assessing the evidence for effective biosafety risk management inOne health (Amsterdam, Netherlands) · 2025Review
- Mechanistic within-host mathematical model of inhalational anthrax.PLoS computational biology · 2025Article
- A within-host birth-death and time-dose-response model for Legionnaires' disease.Royal Society open science · 2025Article
- Q Fever-Related Community Infections: United States Exposure toPathogens (Basel, Switzerland) · 2025Article
- Which Factors Influence the Consumption of Antibiotics in Q-Fever-Positive Dairy Farms in Northern Germany?Animals : an open access journal from MDPI · 2024Article
- Using mixture density networks to emulate a stochastic within-host model of Francisella tularensis infection.PLoS computational biology · 2023Article
- Tracking the Source of Human Q Fever from a Southern French Village: Sentinel Animals and Environmental Reservoir.Microorganisms · 2023Article
- Contemporary diagnostics for medically relevant fastidious microorganisms belonging to the genera Anaplasma,Bartonella,Coxiella,OrientiaandRickettsia.FEMS microbiology reviews · 2022Article
- Serological Prevalence of and Risk Factors forInternational journal of environmental research and public health · 2022Article
- A Stochastic Intracellular Model of Anthrax Infection With Spore Germination Heterogeneity.Frontiers in immunology · 2021Article
- A Novel Marmoset (Frontiers in cellular and infection microbiology · 2020Article
- Theoretical investigation of stochastic clearance of bacteria: first-passage analysis.Journal of the Royal Society, Interface · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The causative agent of Q fever, Coxiella burnetii, has the potential to be developed for use in biological warfare and it is classified as a bioterrorism threat agent by the Centers for Disease Control and Prevention (CDC) and as a category B select agent by the National Institute of Allergy and Infectious Diseases (NIAID). In this paper we focus on the in-host properties that arise when an individual inhales a dose of C. burnetii and establish a human time-dose response model. We also propagate uncertainty throughout the model allowing us to robustly estimate key properties including the infectious dose and incubation period. Using human study data conducted in the 1950's we conclude that the dose required for a 50% probability of infection is about 15 organisms, and that one inhaled organism of C. burnetti can cause infection in 5% of the exposed population. In addition, we derive a low dose incubation period of 17.6 days and an extracellular doubling time of half a day. In conclusion this paper provides a framework for detailing the parameters and approaches that would be required for risk assessments associated with exposures to C. burnetii that might cause human infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.