ArticleBMC biology2017
Olfactory coding from the periphery to higher brain centers in the Drosophila brain.
Article in BMC biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Article
- New dimensions in the molecular genetics of insect chemoreception.Trends in genetics : TIG · 2025Review
- Article
- Response Plasticity ofInternational journal of molecular sciences · 2024Article
- Heterogeneous receptor expression underlies non-uniform peptidergic modulation of olfaction in Drosophila.Nature communications · 2023Article
- Synaptic Development in Diverse Olfactory Neuron Classes Uses Distinct Temporal and Activity-Related Programs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Modulation of the NO-cGMP pathway has no effect on olfactory responses in theFrontiers in cellular neuroscience · 2023Article
- Experience-dependent plasticity in the olfactory system ofFrontiers in cellular neuroscience · 2023Review
- Alzheimer's disease as a fundamental disease of information processing systems: An information theory perspective.Frontiers in neuroscience · 2023Review
- Olfactory responses ofeLife · 2022Article
- Structured sampling of olfactory input by the fly mushroom body.Current biology : CB · 2022Article
- All-optical manipulation of the Drosophila olfactory system.Scientific reports · 2022Article
- Chemoreceptor co-expression ineLife · 2022Article
- Review
- Homeostasis of Mitochondrial CaInsects · 2022Article
- Review
- A Sexually Dimorphic Olfactory Neuron Mediates Fixed Action Transition during Courtship Ritual inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Neural network features distinguish chemosensory stimuli in Caenorhabditis elegans.PLoS computational biology · 2021Article
- Antennal-lobe neurons in the moth Helicoverpa armigera: Morphological features of projection neurons, local interneurons, and centrifugal neurons.The Journal of comparative neurology · 2021Article
- Darwin, sexual selection, and the brain.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundOdor information is processed through multiple receptor-glomerular channels in the first order olfactory center, the antennal lobe (AL), then reformatted into higher brain centers and eventually perceived by the fly. To reveal the logic of olfaction, it is fundamental to map odor representations from the glomerular channels into higher brain centers.
resultsWe characterize odor response profiles of AL projection neurons (PNs) originating from 31 glomeruli using whole cell patch-clamp recordings in Drosophila melanogaster. We reveal that odor representation from olfactory sensory neurons to PNs is generally conserved, while transformation of odor tuning curves is glomerulus-dependent. Reconstructions of PNs reveal that attractive and aversive odors are represented in different clusters of glomeruli in the AL. These separate representations are preserved into higher brain centers, where attractive and aversive odors are segregated into two regions in the lateral horn and partly separated in the mushroom body calyx.
conclusionsOur study reveals spatial representation of odor valence coding from the AL to higher brain centers. These results provide a global picture of the olfactory circuit design underlying innate odor-guided behavior.
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