ArticleInvestigative ophthalmology & visual science2017
The Effect of Change in Intraocular Pressure on Choroidal Structure in Glaucomatous Eyes.
Article in Investigative ophthalmology & visual science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- The Strain Response to Intraocular Pressure Decrease in the Lamina Cribrosa of Patients with Glaucoma.Ophthalmology. GlaucomaTrial
- Ocular Component Growth From the Cornea to the Sclera in Non-Human Primate Emmetropization.Investigative ophthalmology & visual science · 2026Article
- Longitudinal quantitative assessment of macular retinal and choroidal remodeling after trabeculectomy in chronic primary angle-closure glaucoma using ultra-widefield SS-OCTA.Scientific reports · 2025Observational
- Comparable choroidal thickness between treated eyes and untreated fellow-eyes in patients with unilateral neovascular AMD: a paired-eyes comparative study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Analysis of the correlations between changes in posterior segment and anterior chamber segment after implantable collamer lens implantation in highly myopic patients.BMC ophthalmology · 2025Observational
- Three-dimensional choroidal vascularity index and choroidal thickness in fellow eyes of acute and chronic primary angle-closure using swept-source optical coherence tomography.International journal of ophthalmology · 2024Article
- Early evaluation of optic nerve head morphology and choroidal thickness after PreserFlo MicroShunt implantation.International ophthalmology · 2023Observational
- Pressure-Dependent Elevation of Vasoactive Intestinal Peptide Level in Chicken Choroid.Biology · 2023Article
- Choroidal Thickness in Multiple Sclerosis: An Optical Coherence Tomography Study.Journal of clinical neurology (Seoul, Korea) · 2022Article
- Effect of SCUBA Diving on Ophthalmic Parameters.Medicina (Kaunas, Lithuania) · 2022Article
- Choroidal Thickness and Primary Open-Angle Glaucoma-A Narrative Review.Journal of clinical medicine · 2022Review
- Relationship Between Changes in the Choroidal Structure and Blood Flow of the Macula After Trabeculectomy.Translational vision science & technology · 2021Article
- Associations Between the Choroidal Vascularity Index and Malignant Glaucoma After Trabeculectomy for Primary Angle Closure Glaucoma.Frontiers in medicine · 2021Article
- Evaluating Retinal and Choroidal Perfusion Changes After Ocular Massage of Healthy Eyes Using Optical Coherence Tomography Angiography.Medicina (Kaunas, Lithuania) · 2020Article
- Changes in choroidal thickness and optic nerve head morphology after filtering surgery: nonpenetrating deep sclerectomy versus trabeculectomy.BMC ophthalmology · 2019Observational
- Pulse Waveform Analysis of the Ocular Blood Flow Using Laser Speckle Flowgraphy before and after Glaucoma Treatment.Journal of ophthalmology · 2019Article
- Changes in choroidal area following trabeculectomy: Long-term effect of intraocular pressure reduction.PloS one · 2019Article
- Changes in choroidal area after intraocular pressure reduction following trabeculectomy.PloS one · 2018Article
- The impact of obesity on ocular hemodynamics and choroidal thickness.Therapeutic advances in ophthalmologyArticle
- Immediate Choroidal Expansion after Bleb Needling.Case reports in ophthalmologyArticle
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
Purpose: Choroidal thickness increases linearly with intraocular pressure (IOP) lowering. We studied the relationship between the change in size of the choroidal vasculature and IOP lowering after glaucoma procedures. Methods: Thirty eyes of twenty-nine patients were examined pre- and postoperatively for up to 6 months with standard clinical assessment, enhanced depth imaging spectral-domain optical coherence tomography (OCT), and axial length measurement. Each enhanced depth imaging spectral-domain OCT image was analyzed using three separate methods to determine the choroidal thickness, choroidal vessel thickness, choroidal interstitial thickness, large choroidal vessel layer thickness, medium choroidal vessel layer thickness, and light-dark ratio. Bivariate linear regression analysis was completed with largest change in IOP as the independent variable. The dependent variables included choroidal thickness, choroidal vessel thickness, and choroidal interstitial thickness, at the largest change in IOP. Multivariable regression analysis using a generalized estimating equation to account for multiple measurements per eye was also completed. Results: Mean choroidal vessel thickness increases 1.5 μm for every 1 mm Hg decrease in IOP (P < 0.0001; 95% confidence interval [CI], 0.8, 2.1) and choroidal interstitial thickness increases 1.3 μm for every 1 mm Hg change in IOP (P < 0.0001; 95% CI, 0.8, 1.8). There was no significant association between change in IOP and change in large choroidal vessel layer temporally (P = 0.13), nasally (P = 0.20), or subfoveally (P = 0.18). There was also no association between IOP and the light-dark ratio (P = 0.16). Conclusions: The increase in choroidal thickness at lower IOP is associated with approximately equal increases in its intravascular and extravascular compartments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.