ArticleEnvironment international2017
Paternal and maternal urinary phthalate metabolite concentrations and birth weight of singletons conceived by subfertile couples.
Article in Environment international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00011713 (Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes.), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- A systematic review on the role of paternal factors in human placental development, function, and pregnancy-related disorders.Journal of assisted reproduction and genetics · 2025Pooled it
- Paternal Exposure to Endocrine Disrupting Chemicals and Couples' Pregnancy Outcomes: A Qualitative Review of the Literature.Current environmental health reports · 2026Review
- The influence of paternal preconception health on infant birth weight: A scoping review.PloS one · 2026Article
- Personal care product use patterns in association with phthalate and replacement biomarkers across pregnancy.Journal of exposure science & environmental epidemiology · 2024Article
- Associations of parental preconception and maternal pregnancy urinary phthalate biomarker and bisphenol-a concentrations with child eating behaviors.International journal of hygiene and environmental health · 2024Article
- The associations between maternal and fetal exposure to endocrine-disrupting chemicals and asymmetric fetal growth restriction: a prospective cohort study.Frontiers in public health · 2024Article
- Variability and Longitudinal Trajectories of Phthalate and Replacement Biomarkers across Pregnancy in the Human Placenta and Phthalates Study.Environmental science & technology · 2023Article
- Association of preconception mixtures of phenol and phthalate metabolites with birthweight among subfertile couples.Environmental epidemiology (Philadelphia, Pa.) · 2022Article
- Parental Programming of Offspring Health: The Intricate Interplay between Diet, Environment, Reproduction and Development.Biomolecules · 2022Review
- Parental preconception exposure to phenol and phthalate mixtures and the risk of preterm birth.Environment international · 2021Article
- Association of Parental Preconception Exposure to Phthalates and Phthalate Substitutes With Preterm Birth.JAMA network open · 2020Article
- Fetal growth in environmental epidemiology: mechanisms, limitations, and a review of associations with biomarkers of non-persistent chemical exposures during pregnancy.Environmental health : a global access science source · 2019Review
- The extent and predictors of phthalate exposure among couples undergoing in vitro fertilization treatment.Environmental monitoring and assessment · 2019Article
- Placental weight in relation to maternal and paternal preconception and prenatal urinary phthalate metabolite concentrations among subfertile couples.Environmental research · 2019Article
- Cross-sectional associations between urinary triclosan and serum thyroid function biomarker concentrations in women.Environment international · 2019Article
- Urinary Phthalate Metabolites in Common Bottlenose Dolphins (GeoHealth · 2018Article
- Pre-conception susceptibility to endocrine disruptors.Nature reviews. Endocrinology · 2018Article
- Maternal and paternal preconception exposure to bisphenols and size at birth.Human reproduction (Oxford, England) · 2018Article
- Preconception and prenatal urinary concentrations of phenols and birth size of singleton infants born to mothers and fathers from the Environment and Reproductive Health (EARTH) study.Environment international · 2018Article
- Evaluating effects of prenatal exposure to phthalate mixtures on birth weight: A comparison of three statistical approaches.Environment international · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundPrenatal phthalate exposure has been inconsistently associated with fetal growth and infant birth weight. However, the effect of exposure during the paternal and maternal preconception period remains understudied.
objectivesTo investigate associations of paternal and maternal preconception and maternal prenatal urinary phthalate metabolite concentrations with birth weight.
methodsThe study comprised 364 singletons born to 364 mothers and 195 fathers (195 couples) from the EARTH Study, a prospective cohort of couples from Boston, MA. Births were categorized by mode of conception: in-vitro fertilization based (IVF) (n=208) or non-IVF based (n=156, intrauterine insemination or non-medically assisted/natural conception). We measured urinary concentrations of eleven phthalate metabolites in maternal (n=1425) and paternal (n=489) preconception and maternal prenatal (n=781) samples. Birth weight was abstracted from delivery records. Covariate-adjusted associations between log
resultsEach log
conclusionsPaternal preconception urinary concentration of ΣDEHP metabolites was associated with a decrease in birth weight among IVF-conceived singletons. These results, if replicated, highlight the importance of preconception health, especially among subfertile couples.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.