Evidence map›Paper›PMID 28666084›Full record

ReviewBiochemistry2017

Bacterial Cell Mechanics.

George K Auer, Douglas B Weibel

Open access · greenAbstract readReview
In one paragraph

Review in Biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 242 citations in OpenAlex.

  1. Review
  2. Review
  3. Micro-compression analysis of biopolymer-producing bacteria usingCell surface (Amsterdam, Netherlands) · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Green-mediated gold nanoparticles fromBiotechnology notes (Amsterdam, Netherlands) · 2026
    Article
  8. Article
  9. Article
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  11. Article
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  13. Article
  14. Review
  15. Article
  16. Article
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  18. Article
  19. Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

George K AuerDepartment of Biomedical Engineering, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.
Douglas B WeibelDepartment of Biomedical Engineering, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.ORCID 0000-0001-7797-2017
University of Wisconsin–Madison · US

Funding

Revisiting the bacterial cell wall as a target for new antibioticsDP2OD008735 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI WEIBEL, DOUGLAS BENJAMIN · 2011 to 2011
$2.3M
NIH HHS DP2 OD008735
6 · The paper itself

Abstract

Cellular mechanical properties play an integral role in bacterial survival and adaptation. Historically, the bacterial cell wall and, in particular, the layer of polymeric material called the peptidoglycan were the elements to which cell mechanics could be primarily attributed. Disrupting the biochemical machinery that assembles the peptidoglycan (e.g., using the β-lactam family of antibiotics) alters the structure of this material, leads to mechanical defects, and results in cell lysis. Decades after the discovery of peptidoglycan-synthesizing enzymes, the mechanisms that underlie their positioning and regulation are still not entirely understood. In addition, recent evidence suggests a diverse group of other biochemical elements influence bacterial cell mechanics, may be regulated by new cellular mechanisms, and may be triggered in different environmental contexts to enable cell adaptation and survival. This review summarizes the contributions that different biomolecular components of the cell wall (e.g., lipopolysaccharides, wall and lipoteichoic acids, lipid bilayers, peptidoglycan, and proteins) make to Gram-negative and Gram-positive bacterial cell mechanics. We discuss the contribution of individual proteins and macromolecular complexes in cell mechanics and the tools that make it possible to quantitatively decipher the biochemical machinery that contributes to bacterial cell mechanics. Advances in this area may provide insight into new biology and influence the development of antibacterial chemotherapies.

Indexed as

Cell MembraneCell WallGram-Negative BacteriaGram-Positive BacteriaAdaptation, PhysiologicalLipid BilayersLipopolysaccharidesMicrobial ViabilityPeptidoglycanTeichoic AcidsLipid BilayersLipopolysaccharideslipoteichoic acidPeptidoglycanTeichoic Acids

Identifiers

PMID28666084
PMCPMC6260806
OpenAlexW2725399813

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.