ArticleResearch in nursing & health2017
Background and design of the symptom burden in end-stage liver disease patient-caregiver dyad study.
Article in Research in nursing & health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Comparison Between Helpful and Missing Resources Identified by Patients with End-Stage Liver Disease and Their Caregivers: A Content Analysis.Nursing reports (Pavia, Italy) · 2026Article
- Distinct Patterns of Dyadic Mental Health in Patients with End-Stage Liver Disease and Their Care Partners.Healthcare (Basel, Switzerland) · 2026Article
- Longitudinal changes in physical and psychological outcomes in spousal vs. non-spousal caregivers for patients with end-stage liver disease.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Article
- Role of Uncertainty in Illness and Coping Strategies in Advance Directive Completion in Patients With End-stage Liver Disease.Journal of clinical gastroenterology · 2025Article
- Symptom Classes in Decompensated Liver Disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022Article
- Symptom Frequency and Distress Underestimated in Decompensated Cirrhosis.Digestive diseases and sciences · 2022Article
- Therapeutic Potential of HNF4α in End-stage Liver Disease.Organogenesis · 2021Review
- Developing Priorities for Palliative Care Research in Advanced Liver Disease: A Multidisciplinary Approach.Hepatology communications · 2021Review
- Physical and Mental Quality of Life in Patients With End-Stage Liver Disease and Their Informal Caregivers.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021Article
- Approaches to Assessing Burden in Caregivers of Patients with Cirrhosis.Journal of clinical and translational hepatology · 2020Article
- Nonhospice Palliative Care Within the Treatment of End-Stage Liver Disease.Hepatology (Baltimore, Md.) · 2020Review
- Psychosocial Support in Liver Transplantation: A Dyadic Study With Patients and Their Family Caregivers.Frontiers in psychology · 2019Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Over half a million Americans are affected by cirrhosis, the cause of end-stage liver disease (ESLD). Little is known about how symptom burden changes over time in adults with ESLD and their informal caregivers, which limits our ability to develop palliative care interventions that can optimize symptom management and quality of life in different patient-caregiver dyads. The purpose of this article is to describe the background and design of a prospective, longitudinal descriptive study, "Symptom Burden in End-Stage Liver Disease Patient-Caregiver Dyads," which is currently in progress. The study is designed to (i) identify trajectories of change in physical and psychological symptom burden in adults with ESLD; (ii) identify trajectories of change in physical and psychological symptom burden in caregivers of adults with ESLD; and (iii) determine predictors of types of patient-caregiver dyads that would benefit from tailored palliative care interventions. We aim for a final sample of 200 patients and 200 caregivers who will be followed over 12 months. Integrated multilevel and latent growth mixture modeling will be used to identify trajectories of change in symptom burden, linking those changes to clinical events, and quality of life outcomes and characterizing types of patient-caregiver dyads based on patient-, caregiver-, and dyad-level factors. Challenges we have encountered include unexpected attrition of study participants, participants not returning their baseline questionnaires, and hiring and training of research staff. The study will lay the foundation for future research and innovation in ESLD, end-of-life and palliative care, and caregiving.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.