ArticlePloS one2017
Hyperuricemia and risk of increased arterial stiffness in healthy women based on health screening in Korean population.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Pooled it
- Association Between TyG-BMI Index and Hyperuricemia in Adult Women.Endocrinology, diabetes & metabolism · 2025Article
- Serum uric acid is independently associated with impaired nitroglycerine-induced vasodilation of the brachial artery in women.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Nonlinear association of cardiometabolic index with hyperuricemia: insights from the NHANES 1999-2018 study.Frontiers in endocrinology · 2025Article
- Article
- Increased Impact of Serum Uric Acid on Arterial Stiffness and Atherosclerosis in Females.Journal of atherosclerosis and thrombosis · 2022Article
- Association between serum uric acid and arterial stiffness in a large-aged 40-70 years old population.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Metabolic biomarkers and long-term blood pressure variability in military young male adults.World journal of clinical cases · 2020Article
- Relationship between Kidney Stone Disease and Arterial Stiffness in a Taiwanese Population.Journal of clinical medicine · 2020Article
- Gender-Specific Association between Serum Uric Acid and Incident Fundus Arteriosclerosis in Chinese Population: A Retrospective Cross-Sectional Study.Scientific reports · 2020Article
- Uric Acid and Arterial Stiffness.Therapeutics and clinical risk management · 2020Review
- Sexual Dimorphism in Obesity-Associated Endothelial ENaC Activity and Stiffening in Mice.Endocrinology · 2019Article
- Article
- Estimated glomerular filtration rate and arterial stiffness in Japanese population: a secondary analysis based on a cross-sectional study.Lipids in health and disease · 2019Article
- Article
- Article
- Gut microbial diversity is associated with lower arterial stiffness in women.European heart journal · 2018Article
- Association between post-transplant serum uric acid levels and kidney transplantation outcomes.PloS one · 2018Article
- Roles of hyperuricemia in metabolic syndrome and cardiac-kidney-vascular system diseases.American journal of translational research · 2018Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperuricemia is a risk factor for cardiovascular disease and is associated with increased arterial stiffness in high-risk populations. However, given the possible sex-related differences in the prevalence of hyperuricemia, the association between elevated serum uric acid (SUA) level and increased arterial stiffness has yielded conflicting results. We investigated the relationship between SUA and arterial stiffness in asymptomatic healthy subjects who underwent a health examination. Subjects who underwent a comprehensive health examination were enrolled. After exclusion of extensive confounding factors, 2,704 healthy subjects with coronary calcium score < 100 were evaluated in the final analysis. All subjects underwent brachial-ankle pulse wave velocity (baPWV) to detect arterial stiffness. The SUA was divided into quartiles for its association with arterial stiffness and was analyzed separately for men and women. The mean SUA level was significantly lower in women than in men. The baPWV was significantly elevated in subjects with the highest quartile of SUA in women, but not in men. After adjusting for age, smoking, systolic blood pressure, body mass index, estimated glomerular filtration rate, fasting plasma glucose, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, and coronary artery calcium score, the highest quartile of SUA in women was significantly associated with increased risk of high baPWV compared with the lowest quartile of SUA (OR = 1.7, p = 0.018), whereas in men, SUA level was not associated with high baPWV. Our study showed that elevated SUA is independently associated with increased baPWV in healthy Korean women, but not in men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.