ArticlePloS one2017
Detection of colonic dysplasia in patients with ulcerative colitis using a targeted fluorescent peptide and confocal laser endomicroscopy: A pilot study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
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- Intrarectal Administration of Adelmidrol plus Hyaluronic Acid Gel Ameliorates Experimental Colitis in Mice and Inhibits Pro-Inflammatory Response in Ex Vivo Cultured Biopsies Derived from Ulcerative Colitis-Affected Patients.International journal of molecular sciences · 2023Article
- Colorectal cancer screening and surveillance in patients with inflammatory bowel disease in 2021.World journal of gastroenterology · 2022Article
- Molecular Endoscopy for the Diagnosis and Therapeutic Monitoring of Colorectal Cancer.Frontiers in oncology · 2022Review
- Confocal laser endomicroscopy in gastro-intestinal endoscopy: technical aspects and clinical applications.Translational gastroenterology and hepatology · 2022Review
- SAGES TAVAC safety and efficacy analysis confocal laser endomicroscopy.Surgical endoscopy · 2021Review
- Molecular Imaging of Ulex Europaeus Agglutinin in Colorectal Cancer Using Confocal Laser Endomicroscopy (With Video).Frontiers in oncology · 2021Article
- Endoscopic molecular imaging in inflammatory bowel disease.Intestinal research · 2021Review
- Serrated lesions of the colon and rectum: Emergent epidemiological data and molecular pathways.Open medicine (Warsaw, Poland) · 2020Review
- Serrated Lesions of the Colon-Rectum: A Focus on New Diagnostic Tools and Current Management.Gastroenterology research and practice · 2019Review
- Oncological Outcomes and Quality of Life After Rectal Cancer Surgery.Open medicine (Warsaw, Poland) · 2019Article
- Molecular endoscopic imaging: the future is bright.Therapeutic advances in gastrointestinal endoscopyReview
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTargeted molecular probes have been used to detect sporadic colonic dysplasia during confocal laser endomicroscopy (CLE) with promising results. This is a feasibility pilot study aiming to assess the potential role of CLE combined with a fluorescent-labeled peptide to stain and detect dysplasia associated with Ulcerative Colitis.
methodA phage-derived heptapeptide with predicted high binding affinity for dysplastic tissue, was synthesized and labeled with fluorescein. Eleven lesions with suspected dysplasia at endoscopy were excised from nine patients with long-standing ulcerative colitis. Specimens were sprayed with the peptide and examined by CLE. The CLE images were then compared to the corresponding histological sections.
resultsAt definitive histology, 4 lesions were diagnosed as inflammatory polyps, 6 as dysplastic lesions and one as invasive cancer. In inflammatory polyps, the fluorescence signal came from peri-cryptal spaces and crypt lumen due to passive accumulation of the peptide in these areas. Dysplasia was associated with active binding of the peptide to dysplastic colonocytes.
conclusionEx vivo staining of ulcerative colitis-associated dysplasia using a fluorescent labeled molecular probe and CLE is feasible. In vivo studies on larger populations are required to evaluate the safety and the effective contribution of molecular probes in cancer surveillance of ulcerative colitis.
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