SynthesisPLoS neglected tropical diseases2017
Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis.
Synthesis in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Agreement between results of meta-analyses from case reports and clinical studies, regarding efficacy and safety of idursulfase therapy in patients with mucopolysaccharidosis type II (MPS-II). A new tool for evidence-based medicine in rare diseases.Orphanet journal of rare diseases · 2019Pooled it
- Clinical outcomes of current medical approaches for Middle East respiratory syndrome: A systematic review and meta-analysis.Reviews in medical virology · 2018Pooled it
- The varying neuroradiological manifestations of pediatric dengue central nervous system infection: a pictorial review from Pakistan with literature correlation.Pediatric radiology · 2026Review
- [Neurological complications of dengue fever in adults at Ouagadougou university hospitals during the 2023 epidemic in Burkina Faso].Medecine tropicale et sante internationale · 2026Article
- Acute Disseminated Encephalomyelitis (ADEM): Current View into Etiopathogenesis and Clinical Features.Brain sciences · 2026Review
- Myelin-oligodendrocyte glycoprotein (MOG) antibody-associated acute disseminated encephalomyelitis (ADEM) in an adult with dengue.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Severe dengue in adults admitted to intensive care units on réunion island: clinical spectrum, outcomes, and predictors of mortality.Critical care (London, England) · 2025Article
- Viruses and the Brain-A Relationship Prone to Trouble.Viruses · 2025Review
- Article
- New biomarkers for liver involvement by dengue infection in adult Vietnamese patients: a case-control study.BMC infectious diseases · 2024Article
- Catastrophic tumefactive acute disseminated encephalomyelitis in patient with dengue virus: a case report.Journal of neurovirology · 2024Article
- Mechanism of Immune Evasion in Mosquito-Borne Diseases.Pathogens (Basel, Switzerland) · 2023Review
- Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study.PLoS neglected tropical diseases · 2023Article
- Article
- A case report of acute disseminated encephalomyelitis following severe dengue in a child.Germs · 2020Article
- Epstein-Barr Virus Infection in the Development of Neurological Disorders.Drug discovery today. Disease models · 2020Article
- Clinical Features, Diagnosis, and Outcome of Encephalitis in French Guiana.The American journal of tropical medicine and hygiene · 2019Article
- Case Report: Right Hemispheric Neuroimaging Abnormalities in a Patient with Dengue Encephalopathy.The American journal of tropical medicine and hygiene · 2018Article
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDengue is one of the most common infectious diseases. The aim of this study was to systematically review acute disseminated encephalomyelitis (ADEM) and to represent a new case. METHODOLOGY/PRINCIPAL
findingsWe searched for articles in nine databases for case reports, series or previous reviews reporting ADEM cases in human. We used Fisher's exact and Mann-Whitney U tests. Classification trees were used to find the predictors of the disease outcomes. We combined findings using fixed- and random-effects models. A 13-year-old girl was admitted to the hospital due to fever. She has a urinary retention. The neurological examinations revealed that she became lethargic and quadriplegic. She had upper limbs weakness and lower limbs complete paraplegia. Her status gradually improved after the treatment. She was nearly intact with the proximal part of her legs had a mild weakness in discharge. The prevalence of ADEM among dengue patients was 0.4% [95% confidence intervals (95% CI) 0.1-2.5%], all neurological disorders among dengue was 2.6% [95% CI 1.8-3.8%], and ADEM among neurological disorders was 6.8% [95% CI 3.4-13%]. The most frequent manifestation of ADEM was altered sensorium/consciousness (58%), seizures and urination problems (35%), vision problems (31%), slurred speech (23%), walk problems (15%) then ataxia (12%). There was a significant difference between cases having complete recovery or bad outcomes in the onset day of neurological manifestations being earlier and in temperature being higher in cases having bad outcomes (p-value < 0.05). This was confirmed by classification trees which included these two variables. CONCLUSIONS/SIGNIFICANCE: The prevalence of ADEM among dengue and other dengue-related neurological disorders is not too rare. The high fever of ADEM cases at admission and earlier onset day of neurological manifestations are associated with the bad outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.