ArticlePediatric research2017
Association of the gut microbiota mobilome with hospital location and birth weight in preterm infants.
Article in Pediatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- The impact of neonatal intensive care unit antibiotics on gut bacterial microbiota of preterm infants: a systematic review.Frontiers in microbiomes · 2023Pooled it
- A systematic review of the factors influencing microbial colonization of the preterm infant gut.Gut microbesPooled it
- Metabolic reprogramming of the infant gut by bifidobacteria-based probiotics drives exclusion of antibiotic-resistant pathobionts.Cell reports. Medicine · 2026Article
- Changes in intestinal bacterial characteristics during hospitalization in the NICU in very low birth weight infants.Italian journal of pediatrics · 2025Article
- Gut microbiota composition in preterm infants with and without necrotizing enterocolitis: a systematic review and narrative synthesis.Access microbiology · 2025Article
- Gut Microbiome-Brain Axis as an Explanation for the Risk of Poor Neurodevelopment Outcome in Preterm Infants with Necrotizing Enterocolitis.Microorganisms · 2023Review
- Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation.Microbiome · 2022Article
- A plasmid network from the gut microbiome of semi-isolated human groups reveals unique and shared metabolic and virulence traits.Scientific reports · 2022Article
- Pathogenomes and variations in Shiga toxin production among geographically distinct clones ofMicrobial genomics · 2022Article
- Emerging prediction methods for early diagnosis of necrotizing enterocolitis.Frontiers in medicine · 2022Review
- Experimental support for multidrug resistance transfer potential in the preterm infant gut microbiota.Pediatric research · 2020Observational
- Potential Elimination of Human Gut Resistome by Exploiting the Benefits of Functional Foods.Frontiers in microbiology · 2020Review
- Whole genome sequencing and metagenomics for outbreak investigation, source attribution and risk assessment of food-borne microorganisms.EFSA journal. European Food Safety Authority · 2019Article
- Longitudinal Gut Bacterial Colonization and Its Influencing Factors of Low Birth Weight Infants During the First 3 Months of Life.Frontiers in microbiology · 2019Article
- Maternal gut and breast milk microbiota affect infant gut antibiotic resistome and mobile genetic elements.Nature communications · 2018Article
- Effects of Probiotic Supplementation on the Gut Microbiota and Antibiotic Resistome Development in Preterm Infants.Frontiers in pediatrics · 2018Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundThe preterm infant gut microbiota is vulnerable to different biotic and abiotic factors. Although the development of this microbiota has been extensively studied, the mobilome-i.e. the mobile genetic elements (MGEs) in the gut microbiota-has not been considered. Therefore, the aim of this study was to investigate the association of the mobilome with birth weight and hospital location in the preterm infant gut microbiota.MethodsThe data set consists of fecal samples from 62 preterm infants with and without necrotizing enterocolitis (NEC) from three different hospitals. We analyzed the gut microbiome by using 16S rRNA amplicon sequencing, shot-gun metagenome sequencing, and quantitative PCR. Predictive models and other data analyses were performed using MATLAB and QIIME.ResultSThe microbiota composition was significantly different between NEC-positive and NEC-negative infants and significantly different between hospitals. An operational taxanomic unit (OTU) showed strong positive and negative correlation with NEC and birth weight, respectively, whereas none showed significance for mode of delivery. Metagenome analyses revealed high levels of conjugative plasmids with MGEs and virulence genes. Results from quantitative PCR showed that the plasmid signature genes were significantly different between hospitals and in NEC-positive infants.ConclusionOur results point toward an association of the mobilome with hospital location in preterm infants.
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