ArticleEnvironmental health perspectives2017
Maternal and Cord Blood Manganese Concentrations and Early Childhood Neurodevelopment among Residents near a Mining-Impacted Superfund Site.
Article in Environmental health perspectives, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Effects of Prenatal Arsenic, Cadmium, and Manganese Exposure on Neurodevelopment in Children: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Biomarkers of environmental manganese exposure and associations with childhood neurodevelopment: a systematic review and meta-analysis.Environmental health : a global access science source · 2020Pooled it
- Using transcriptomic signatures to elucidate individual and mixture effects of inorganic arsenic and manganese in human placental trophoblast HTR-8/SVneo cells.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Occupational, environmental, and toxicological health risks of mining metals for lithium-ion batteries: a narrative review of the Pubmed database.Journal of occupational medicine and toxicology (London, England) · 2024Review
- Prenatal metal concentrations and physical abnormalities in the Japan Environment and Children's Study.Pediatric research · 2024Article
- Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants.Environmental health perspectives · 2024Article
- Prenatal manganese biomarkers and operant test battery performance in Mexican children: Effect modification by child sex.Environmental research · 2023Article
- Sex-specific association between prenatal manganese exposure and working memory in school-aged children in Mexico city: An exploratory multi-media approach.Environmental pollution (Barking, Essex : 1987) · 2023Article
- Exposure to metal mixtures and neuropsychological functioning in middle childhood.Neurotoxicology · 2022Article
- Maternal Metals Exposure and Infant Weight Trajectory: The Japan Environment and Children's Study (JECS).Environmental health perspectives · 2022Article
- Umbilical cord serum elementomics of 52 trace elements and early childhood neurodevelopment: Evidence from a prospective birth cohort in rural Bangladesh.Environment international · 2022Article
- Associations of Heavy Metals with Activities of Daily Living Disability: An Epigenome-Wide View of DNA Methylation and Mediation Analysis.Environmental health perspectives · 2022Article
- Multiple metals in children's deciduous teeth: results from a community-initiated pilot study.Journal of exposure science & environmental epidemiology · 2022Article
- Association between prenatal metal exposure and adverse respiratory symptoms in childhood.Environmental research · 2022Article
- Differences and Interactions in Placental Manganese and Iron Transfer across an In Vitro Model of Human Villous Trophoblasts.International journal of molecular sciences · 2022Article
- Exposure to environmental chemicals and perinatal psychopathology.Biochemical pharmacology · 2022Review
- Prenatal Metal Exposures and Infants' Developmental Outcomes in a Navajo Population.International journal of environmental research and public health · 2021Article
- Critical windows of susceptibility in the association between manganese and neurocognition in Italian adolescents living near ferro-manganese industry.Neurotoxicology · 2021Article
- Cord Blood Manganese Concentrations in Relation to Birth Outcomes and Childhood Physical Growth: A Prospective Birth Cohort Study.Nutrients · 2021Article
- Prenatal exposure to a mixture of elements and neurobehavioral outcomes in mid-childhood: Results from Project Viva.Environmental research · 2021Article
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundEnvironmental manganese exposure has been associated with adverse neurodevelopmental outcomes among school-aged children; yet, few studies have evaluated prenatal exposure.
objectivesOur study examines associations between prenatal manganese concentrations and placental transfer of manganese with neurodevelopment in 224 2-y-old children residing near the Tar Creek Superfund Site.
methodsWe collected maternal and cord blood at delivery, measured manganese using inductively coupled plasma mass spectrometry, and assessed neurodevelopment using the Bayley Scales of Infant Development-II. Associations between manganese and mental (MDI) and psychomotor (PDI) development indices were estimated in multivariable models. Placental transfer, approximated by cord/maternal manganese ratio, cord/total manganese ratio (total=maternal+cord), and by joint classification according to high or low (above or below median) maternal and cord manganese, was evaluated as a predictor of neurodevelopment.
resultsMedian levels [interquartile ranges (IQR)] of manganese in maternal and cord blood, respectively, were 24.0 (19.5-29.7) and 43.1 (33.5-52.1) μg/L. Adjusting for lead, arsenic, and other potential confounders, an IQR increase in maternal manganese was associated with -3.0 (95% CI: -5.3, -0.7) points on MDI and -2.3 (95% CI: -4.1, -0.4) points on PDI. Cord manganese concentrations were not associated with neurodevelopment scores. Cord/maternal and cord/total manganese ratios were positively associated with MDI [cord/maternal: β=2.6 (95% Cl: −0.04, 5.3); cord/total: β=22.0 (95% Cl: 3.2, 40.7)] and PDI (cord/maternal: β=1.7 (95% Cl: −0.5, 3.9); cord/total: β=15.6 (95% Cl: 0.3, 20.9)). Compared to mother-child pairs with low maternal and cord manganese, associations with neurodevelopment scores were negative for pairs with either high maternal, high cord, or high maternal and cord manganese.
conclusionsMaternal blood manganese concentrations were negatively associated with early childhood neurodevelopment scores in our study. Findings highlight the importance of understanding maternal exposures during pregnancy and factors influencing placental transfer. https://doi.org/10.1289/EHP925.
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