Evidence map›Paper›PMID 28665784›Full record

ArticleRNA biology2017

The evidence for a microRNA product of human DROSHA gene.

Peter Mechtler, Sydney Johnson, Hannah Slabodkin, Amir B Cohanim, Leonid Brodsky, Eugene S Kandel

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. 44 Current Challenges in miRNomics.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  4. Auto-regulatory feedback by RNA-binding proteins.Journal of molecular cell biology · 2019
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Peter Mechtlera Department of Cell Stress Biology, Roswell Park Cancer Institute , Elm and Carlton Streets, Buffalo , NY , USA.
Sydney Johnsona Department of Cell Stress Biology, Roswell Park Cancer Institute , Elm and Carlton Streets, Buffalo , NY , USA.
Hannah Slabodkina Department of Cell Stress Biology, Roswell Park Cancer Institute , Elm and Carlton Streets, Buffalo , NY , USA.
Amir B Cohanimb Tauber Bioinformatics Research Center , University of Haifa , Mount Carmel , Haifa , Israel.
Leonid Brodskyb Tauber Bioinformatics Research Center , University of Haifa , Mount Carmel , Haifa , Israel.
Eugene S Kandela Department of Cell Stress Biology, Roswell Park Cancer Institute , Elm and Carlton Streets, Buffalo , NY , USA.
Roswell Park Comprehensive Cancer Center · USUniversity of Haifa · IL

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6M
NCI NIH HHS P30 CA016056
6 · The paper itself

Abstract

MicroRNAs are short RNA molecules that regulate function and stability of a large subset of eukaryotic mRNAs. In the main pathway of microRNA biogenesis, a short "hairpin" is excised from a primary transcript by ribonuclease DROSHA, followed by additional nucleolytic processing by DICER and inclusion of the mature microRNA into the RNA-induced silencing complex. We report that a microRNA-like molecule is encoded by human DROSHA gene within a predicted stem-loop element of the respective transcript. This putative mature microRNA is complementary to DROSHA transcript variant 1 and can attenuate expression of the corresponding protein. The findings suggest a possibility for a negative feedback loop, wherein DROSHA processes its own transcript and produces an inhibitor of its own biosynthesis.

Indexed as

RNA Processing, Post-TranscriptionalBase PairingBase SequenceCell Line, TransformedDEAD-box RNA HelicasesForkhead Box Protein O1HEK293 CellsHumansMicroRNAsNucleic Acid ConformationRibonuclease IIIRNA-Induced Silencing ComplexRNA, MessengerDEAD-box RNA HelicasesDICER1 protein, humanDROSHA protein, humanForkhead Box Protein O1FOXO1 protein, humanMicroRNAsRibonuclease IIIRNA-Induced Silencing ComplexRNA, MessengerDROSHAmicroRNA biogenesisRNA interference

Identifiers

PMID28665784
PMCPMC5785223
OpenAlexW2726728286

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.