Evidence map›Paper›PMID 28665588›Full record

ArticleBiochemistry2017

Biochemical Investigation of Rv3404c from Mycobacterium tuberculosis.

Murray M Dunsirn, James B Thoden, Michel Gilbert, Hazel M Holden

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Biochemical analysis of a sugar 4,6-dehydratase from Acanthamoeba polyphaga Mimivirus.Protein science : a publication of the Protein Society · 2020
    Article
  4. Misannotations of the genes encoding sugar N-formyltransferases.Protein science : a publication of the Protein Society · 2020
    Article
  5. Investigation of a sugar N-formyltransferase from the plant pathogen Pantoea ananatis.Protein science : a publication of the Protein Society · 2019
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Murray M DunsirnDepartment of Biochemistry, University of Wisconsin , Madison, Wisconsin 53706, United States.
James B ThodenDepartment of Biochemistry, University of Wisconsin , Madison, Wisconsin 53706, United States.
Michel GilbertNational Research Council Canada, Human Health Therapeutics, Ottawa, Ontario K1A 0R6, Canada.
Hazel M HoldenDepartment of Biochemistry, University of Wisconsin , Madison, Wisconsin 53706, United States.ORCID 0000-0001-6214-3638

Funding

X-ray Studies of Sugar-Modifying EnzymesR01GM115921 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HOLDEN, HAZEL M. · 2016 to 2019
$1.4M
NIGMS NIH HHS R01 GM115921
6 · The paper itself

Abstract

The causative agent of tuberculosis, Mycobacterium tuberculosis, is a bacterium with a complex cell wall and a complicated life cycle. The genome of M. tuberculosis contains well over 4000 genes thought to encode proteins. One of these codes for a putative enzyme referred to as Rv3404c, which has attracted research attention as a potential virulence factor for over 12 years. Here we demonstrate that Rv3404c functions as a sugar N-formyltransferase that converts dTDP-4-amino-4,6-dideoxyglucose into dTDP-4-formamido-4,6-dideoxyglucose using N

Indexed as

Models, MolecularBacterial ProteinsCatalysisCrystallography, X-RayDeoxy SugarsFormyltetrahydrofolatesHydroxymethyl and Formyl TransferasesKineticsMycobacterium tuberculosisThymine NucleotidesVirulence FactorsBacterial ProteinsDeoxy SugarsdTDP-4-amino-4,6-dideoxy-glucoseFormyltetrahydrofolatesHydroxymethyl and Formyl TransferasesThymine NucleotidesVirulence Factors

Identifiers

PMID28665588
PMCPMC5644030

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.