Evidence map›Paper›PMID 28665402›Full record

ArticleCell death and differentiation2017

Germline BAP1 mutations induce a Warburg effect.

Angela Bononi, Haining Yang, Carlotta Giorgi, Simone Patergnani, Laura Pellegrini, Mingming Su, Guoxiang Xie, Valentina Signorato, Sandra Pastorino, Paul Morris and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Cell death and differentiation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 138 citations in OpenAlex.

  1. Article
  2. TruncatingbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Advances in the Basic Sciences in Thoracic Oncology in the Last 20 Years and Their Translational Impact.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Pleural mesothelioma.Nature reviews. Disease primers · 2025
    Review
  12. Review
  13. Article
  14. An overview of BAP1 biological functions and current therapeutics.Biochimica et biophysica acta. Reviews on cancer · 2025
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Angela BononiThoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Haining YangThoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Carlotta GiorgiDepartment of Morphology-Surgery-Experimental Medicine, University of Ferrara, Ferrara, Italy.
Simone PatergnaniDepartment of Morphology-Surgery-Experimental Medicine, University of Ferrara, Ferrara, Italy.
Laura PellegriniThoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Mingming SuMetabolomics Unit, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Guoxiang XieMetabolomics Unit, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Valentina SignoratoThoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Sandra PastorinoThoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Paul MorrisThoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Greg SakamotoThoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Shafi KuchayCancer Center, New York University, New York, NY 10016, USA.
Giovanni GaudinoThoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.ORCID 0000-0002-1572-6571
Harvey I PassCancer Center, New York University, New York, NY 10016, USA.
Andrea NapolitanoThoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Paolo PintonDepartment of Morphology-Surgery-Experimental Medicine, University of Ferrara, Ferrara, Italy.ORCID 0000-0001-7108-6508
Wei JiaMetabolomics Unit, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Michele CarboneThoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
University of Hawaiʻi at Mānoa · USUniversity of Ferrara · ITNew York University · US

Funding

University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2M
The North American Mesothelioma ConsortiumU01CA111295 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HUFLEJT, MARGARET ELISABETH, PASS, HARVEY IRA · 2005 to 2016
$4.8M
Germline BAP1 Mutations and Malignant Mesothelioma: Mechanisms and Early DetectionR01CA198138 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI CARBONE, MICHELE · 2015 to 2019
$1.7M
The Role of HMGB1 in the Pathogenesis of MesotheliomaR01CA160715 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI YANG, HAINING · 2011 to 2015
$1.5M
NCI NIH HHS P30 CA071789NCI NIH HHS R01 CA160715NCI NIH HHS R01 CA198138NCI NIH HHS U01 CA111295
6 · The paper itself

Abstract

Carriers of heterozygous germline BAP1 mutations (BAP1

Indexed as

Germ CellsHeterozygoteHumansMitochondriaMutationSkinTumor Suppressor ProteinsUbiquitin ThiolesteraseBAP1 protein, humanTumor Suppressor ProteinsUbiquitin Thiolesterase

Identifiers

PMID28665402
PMCPMC5596430
OpenAlexW2734271067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.