Evidence map›Paper›PMID 28665355›Full record

ArticleInternational journal of environmental research and public health2017

In Silico Prediction for Intestinal Absorption and Brain Penetration of Chemical Pesticides in Humans.

Lisa Chedik, Dominique Mias-Lucquin, Arnaud Bruyere, Olivier Fardel

Abstract read
In one paragraph

Article in International journal of environmental research and public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Inhibition of Shiga Toxin 2 forCurrent medicinal chemistry · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lisa ChedikInstitut de Recherche en Santé, Environnement et Travail (IRSET), UMR INSERM U1085, Faculté de Pharmacie, Université de Rennes 1, 2 Avenue du Pr Léon Bernard, 35043 Rennes, France. lisa.chedik@univ-rennes1.fr.
Dominique Mias-LucquinInstitut de Génétique et Développement de Rennes, UMR CNRS 6290, Université de Rennes 1, 35043 Rennes, France. dominique.mias-lucquin@univ-rennes1.fr.
Arnaud BruyereInstitut de Recherche en Santé, Environnement et Travail (IRSET), UMR INSERM U1085, Faculté de Pharmacie, Université de Rennes 1, 2 Avenue du Pr Léon Bernard, 35043 Rennes, France. arnaud.bruyere@univ-rennes1.fr.
Olivier FardelInstitut de Recherche en Santé, Environnement et Travail (IRSET), UMR INSERM U1085, Faculté de Pharmacie, Université de Rennes 1, 2 Avenue du Pr Léon Bernard, 35043 Rennes, France. olivier.fardel@univ-rennes1.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal absorption and brain permeation constitute key parameters of toxicokinetics for pesticides, conditioning their toxicity, including neurotoxicity. However, they remain poorly characterized in humans. The present study was therefore designed to evaluate human intestine and brain permeation for a large set of pesticides (

Indexed as

BrainComputer SimulationHumansIntestinal AbsorptionModels, BiologicalNeurotoxicity SyndromesPesticidesPesticidesbrain permeationin silico methodintestinal absorptionpesticidespredictiontoxicitytoxicokinetics

Identifiers

PMID28665355
PMCPMC5551146

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.