ArticlePhysics in medicine and biology2017
Design of patient-specific focused ultrasound arrays for non-invasive brain therapy with increased trans-skull transmission and steering range.
Article in Physics in medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Flexible ultrasound array for subcortical brain stimulation in humans: a simulation study.NPJ acoustics · 2026Article
- The role of focused ultrasound for pediatric brain tumors: current insights and future implications on treatment strategies.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Generating Patient-Specific Acoustic Simulations for Transcranial Focused Ultrasound Procedures Based on Optical Tracking Information.IEEE open journal of ultrasonics, ferroelectrics, and frequency control · 2023Article
- Focused ultrasound: growth potential and future directions in neurosurgery.Journal of neuro-oncology · 2022Review
- Implementation of a Skull-Conformal Phased Array for Transcranial Focused Ultrasound Therapy.IEEE transactions on bio-medical engineering · 2021Article
- Therapeutic Agent Delivery Across the Blood-Brain Barrier Using Focused Ultrasound.Annual review of biomedical engineering · 2021Review
- Technical Comparison of Treatment Efficiency of Magnetic Resonance-Guided Focused Ultrasound Thalamotomy and Pallidotomy in Skull Density Ratio-Matched Patient Cohorts.Frontiers in neurology · 2021Article
- Applications of focused ultrasound in the brain: from thermoablation to drug delivery.Nature reviews. Neurology · 2021Review
- A Noninvasive Ultrasound Resonance Method for Detecting Skull Induced Phase Shifts May Provide a Signal for Adaptive Focusing.IEEE transactions on bio-medical engineering · 2020Article
- Numerical Evaluation of the Influence of Skull Heterogeneity on Transcranial Ultrasonic Focusing.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The use of a phased array of ultrasound transducer elements to sonicate through the skull has opened the way for new treatments and the delivery of therapeutics beyond the blood-brain barrier. The limited steering range of current clinical devices, particularly at higher frequencies, limits the regions of the brain that are considered treatable by ultrasound. A new array design is introduced that allows for high levels of beam steering and increased transmission throughout the brain. These improvements are achieved using concave transducers normal to the outer-skull surface in a patient-specific configuration to target within the skull, so that the far-field of each beam is within the brain. It is shown that by using pulsed ultrasound waves timed to arrive in-phase at the desired target, sufficient levels of acoustic energy are delivered for blood-brain barrier opening throughout the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.