Evidence map›Paper›PMID 28665044›Full record

ArticleBipolar disorders2017

Mood symptoms in pregnant and postpartum women with bipolar disorder: a naturalistic study.

Kara E Driscoll, Dorothy K Y Sit, Eydie L Moses-Kolko, Emily Pinheiro, Amy Yang, Jody D Ciolino, Heather F Eng, James F Luther, Crystal T Clark, Stephen R Wisniewski and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bipolar disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Kara E DriscollUniversity of Pittsburgh, Pittsburgh, PA, USA.
Dorothy K Y SitNorthwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Eydie L Moses-KolkoUniversity of Pittsburgh, Pittsburgh, PA, USA.
Emily PinheiroNorthwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Amy YangNorthwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Jody D CiolinoNorthwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Heather F EngDepartment of Epidemiology, Graduate School of Public Health, Epidemiology Data Center, University of Pittsburgh, Pittsburgh, PA, USA.
James F LutherDepartment of Epidemiology, Graduate School of Public Health, Epidemiology Data Center, University of Pittsburgh, Pittsburgh, PA, USA.
Crystal T ClarkNorthwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Stephen R WisniewskiDepartment of Epidemiology, Graduate School of Public Health, Epidemiology Data Center, University of Pittsburgh, Pittsburgh, PA, USA.
Katherine L WisnerNorthwestern University, Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0003-3458-5986
Northwestern University · USUniversity of Pittsburgh · US

Funding

NIMH NIH HHS L30 MH101833
6 · The paper itself

Abstract

objectiveWe conducted a prospective naturalistic study of pregnant women with bipolar disorder (BD) to evaluate symptoms of BD across childbearing and assess whether pharmacotherapy reduced their severity.

methodsAssessments were scheduled at 20, 30, and 36 weeks' gestation and 2, 12, 26, and 52 weeks postpartum. Symptoms were assessed using the Structured Interview Guide for the Hamilton Depression Rating Scale-Atypical Depression Supplement (SIGH-ADS) and Mania Rating Scale (MRS).

resultsPregnant women (N=152) with BD were evaluated; 88 women (58%) were treated and 64 untreated (42%) with psychotropic drugs during pregnancy. Among the 88 women treated, 23 (26%) discontinued their medication in the first trimester and the remaining 65 (74%) were exposed throughout pregnancy or in the second and third trimesters. More than two-thirds (73%) of the women who remained in the study took psychotropic agents postpartum. The mean scores on the SIGH-ADS were in the mild range of depressive symptoms in both the psychotropic-treated and untreated groups in both pregnancy and postpartum. The majority of women had no or few symptoms of mania. Of the pregnant women treated with psychotropic agents, 66% received a guideline-concordant drug, and 34% received either antidepressant monotherapy (for BD I) or mono- or polypharmacy with a variety of other agents.

conclusionsThis sample of perinatal women with BD was characterized by mild residual symptoms of depression independent of pharmacotherapy, which poses a risk for recurrence and impaired parenting. The treatment of childbearing women with BD deserves urgent clinical and research attention to improve psychiatric outcomes.

Indexed as

Bipolar DisorderPregnancy ComplicationsPuerperal DisordersAdultFemaleGestational AgeHumansMedication Therapy ManagementOutcome and Process Assessment, Health CarePerinatal CarePostpartum PeriodPregnancyPregnant PeopleProspective StudiesPsychiatric Status Rating ScalesPsychotropic DrugsPsychotropic Drugsbipolar disordermental healthperinatalpharmacokineticspregnancyPsychotropic agents

Identifiers

PMID28665044
PMCPMC6594856
OpenAlexW2727523671

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.