Evidence map›Paper›PMID 28664928›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017

Co-Activation of Metabotropic Glutamate Receptor 3 and Beta-Adrenergic Receptors Modulates Cyclic-AMP and Long-Term Potentiation, and Disrupts Memory Reconsolidation.

Adam G Walker, Douglas J Sheffler, Andrew S Lewis, Jonathan W Dickerson, Daniel J Foster, Rebecca K Senter, Mark S Moehle, Xiaohui Lv, Branden J Stansley, Zixiu Xiang and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Advances in translating mGluPharmacology, biochemistry, and behavior · 2022
    Review
  5. Review
  6. Article
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Adam G WalkerDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
Douglas J ShefflerCancer Metabolism and Signaling Networks Program, Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Andrew S LewisDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
Jonathan W DickersonDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
Daniel J FosterDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
Rebecca K SenterDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
Mark S MoehleDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
Xiaohui LvDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
Branden J StansleyDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
Zixiu XiangDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-1678-209X
Jerri M RookDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
Kyle A EmmitteDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
Craig W LindsleyDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
P Jeffrey ConnDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
Vanderbilt University · USSanford Burnham Prebys Medical Discovery Institute · US

Funding

REGULATION OF SIGNALING BY MGLUR5R01MH062646 · NIMH · VANDERBILT UNIVERSITY · PI P Jeffrey Conn, COLLEEN M NISWENDER · 2001 to 2026
$10.9M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPESR01NS031373 · NINDS · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY · 1993 to 2025
$6.2M
Functions of Metabotropic Glutamate Receptor SubtypesR37NS031373 · NINDS · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY · 2014 to 2020
$3.5M
NICHD NIH HHS U54 HD083211NIMH NIH HHS R01 MH062646NINDS NIH HHS R01 NS031373NINDS NIH HHS R37 NS031373
6 · The paper itself

Abstract

Activation of β-adrenergic receptors (βARs) enhances both the induction of long-term potentiation (LTP) in hippocampal CA1 pyramidal cells and hippocampal-dependent cognitive function. Interestingly, previous studies reveal that coincident activation of group II metabotropic glutamate (mGlu) receptors with βARs in the hippocampal astrocytes induces a large increase in cyclic-AMP (cAMP) accumulation and release of adenosine. Adenosine then acts on A

Indexed as

AnimalsCerebral CortexConditioning, PsychologicalCyclic AMPHippocampusLong-Term PotentiationMaleMemory ConsolidationMice, Inbred ICRMice, KnockoutNeurotransmitter AgentsRats, Sprague-DawleyReceptors, Adrenergic, betaReceptors, Metabotropic GlutamateTissue Culture TechniquesCyclic AMPmetabotropic glutamate receptor 2metabotropic glutamate receptor 3Neurotransmitter AgentsReceptors, Adrenergic, betaReceptors, Metabotropic Glutamate

Identifiers

PMID28664928
PMCPMC5686489
OpenAlexW2729329872

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.