Evidence map›Paper›PMID 28664927›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018

Low Striatal Dopamine D2-type Receptor Availability is Linked to Simulated Drug Choice in Methamphetamine Users.

Scott J Moeller, Kyoji Okita, Chelsea L Robertson, Michael E Ballard, Anna B Konova, Rita Z Goldstein, Mark A Mandelkern, Edythe D London

Open access · bronzeAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. The use ofFrontiers in cell and developmental biology · 2026
    Review
  8. Review
  9. Article
  10. Tobacco Images Choice and its Association With Craving and Dependence in People Who Smoke Cigarettes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024
    Article
  11. Article
  12. Article
  13. Candidate biomarkers in psychiatric disorders: state of the field.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023
    Article
  14. Review
  15. Article
  16. Article
  17. Effects of an Adenosine AFrontiers in neuroscience · 2021
    Article
  18. Review
  19. Behavioral preference for viewing drugPsychological medicine · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Scott J MoellerDepartments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kyoji OkitaDepartments of Psychiatry and Biobehavioral Sciences, and Molecular and Medical Pharmacology, University of California Los Angeles (UCLA), Los Angeles, CA, USA.
Chelsea L RobertsonDepartments of Psychiatry and Biobehavioral Sciences, and Molecular and Medical Pharmacology, University of California Los Angeles (UCLA), Los Angeles, CA, USA.
Michael E BallardUniversity of California San Francisco, San Francisco, CA, USA.
Anna B KonovaCenter for Neural Science, New York University, New York, NY, USA.
Rita Z GoldsteinDepartments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mark A MandelkernVeterans Administration of Greater Los Angeles (VAGLA), Los Angeles, CA, USA.
Edythe D LondonDepartments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Icahn School of Medicine at Mount Sinai · USUniversity of California, Los Angeles · USNew York University · USVA Northern California Health Care System · US

Funding

Using event-related potentials to longitudinally track cue-induced craving incubation in cocaine addicted individualsR01DA041528 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GOLDSTEIN, RITA Z · 2016 to 2020
$3.3M
The prefrontal cortex in salience and control in cocaine addiction: phFMRI studyR01DA023579 · NIDA · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI GOLDSTEIN, RITA Z · 2008 to 2012
$2.8M
Genetic markers associated with brain structural abnormalities and drug use in human addictionK01DA037452 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI MOELLER, SCOTT J · 2015 to 2019
$778k
Neuroeconomic investigation of craving in opioid addictionF32DA039648 · NIDA · NEW YORK UNIVERSITY · PI KONOVA, ANNA BORISOVA · 2015 to 2017
$164k
NIDA NIH HHS F32 DA039648NIDA NIH HHS K01 DA037452NIDA NIH HHS R01 DA023579NIDA NIH HHS R01 DA041528
6 · The paper itself

Abstract

Individuals with drug use disorders seek drugs over other rewarding activities, and exhibit neurochemical deficits related to dopamine, which is involved in value-based learning and decision-making. Thus, a dopaminergic disturbance may underpin drug-biased choice in addiction. Classical drug-choice assessments, which offer drug-consumption opportunities, are inappropriate for addicted individuals seeking treatment or abstaining. Fifteen recently abstinent methamphetamine users and 15 healthy controls completed two laboratory paradigms of 'simulated' drug choice (choice for drug-related vs affectively pleasant, unpleasant, and neutral images), and underwent positron emission tomography measurements of dopamine D2-type receptor availability, indicated by binding potential (BP

Indexed as

AdultAmphetamine-Related DisordersChoice BehaviorCorpus StriatumDrug-Seeking BehaviorFemaleHumansMaleMethamphetamineMiddle AgedPhotic StimulationPositron-Emission TomographyPrefrontal CortexPsychomotor PerformanceReceptors, Dopamine D2RewardDRD2 protein, humanMethamphetamineReceptors, Dopamine D2

Identifiers

PMID28664927
PMCPMC5809782
OpenAlexW2727587395

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.