Evidence map›Paper›PMID 28664456›Full record

ArticleTransgenic research2017

Pancreas specific expression of oncogenes in a porcine model.

Martin F Berthelsen, Morten M Callesen, Tanja S Østergaard, Ying Liu, Rong Li, Henrik Callesen, Frederik Dagnæs-Hansen, Stephen Hamilton-Dutoit, Jannik E Jakobsen, Martin K Thomsen

Abstract read
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In one paragraph

Article in Transgenic research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Pigs: Large Animal Preclinical Cancer Models.World journal of oncology · 2024
    Review
  2. Article
  3. Article
  4. Genetically Engineered Pigs to Study Cancer.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Martin F BerthelsenDepartment of Clinical Medicine, Aarhus University, 8200, Aarhus N, Denmark.
Morten M CallesenDepartment of Clinical Medicine, Aarhus University, 8200, Aarhus N, Denmark.
Tanja S ØstergaardDepartment of Clinical Medicine, Aarhus University, 8200, Aarhus N, Denmark.
Ying LiuDepartment of Animal Science, Aarhus University, 8830, Tjele, Denmark.
Rong LiDepartment of Animal Science, Aarhus University, 8830, Tjele, Denmark.
Henrik CallesenDepartment of Animal Science, Aarhus University, 8830, Tjele, Denmark.
Frederik Dagnæs-HansenDepartment of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark.
Stephen Hamilton-DutoitInstitute of Pathology, Aarhus University Hospital, 8000, Aarhus C, Denmark.
Jannik E JakobsenDepartment of Clinical Medicine, Aarhus University, 8200, Aarhus N, Denmark.
Martin K ThomsenDepartment of Clinical Medicine, Aarhus University, 8200, Aarhus N, Denmark. mkt@clin.au.dk.
Aarhus University · DKAarhus University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic cancer is the fourth leading course of cancer death and early detection of the disease is crucial for successful treatment. However, pancreatic cancer is difficult to detect in its earliest stages and once symptoms appear, the cancer has often progressed beyond possibility for curing. Research into the disease has been hampered by the lack of good models. We have generated a porcine model of pancreatic cancer with use of transgenic overexpression of an oncogene cassette containing MYC, KRAS

Indexed as

Animals, Genetically ModifiedAnimalsCell Line, TumorCell ProliferationCell Transformation, NeoplasticDisease Models, AnimalGene Expression Regulation, NeoplasticGenes, mycHumansPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)Signal TransductionSwineKRAS protein, humanProto-Oncogene Proteins p21(ras)Gene activation and repressionOncogenesPancreatic cancerPig modelSomatic cell nuclear transfer

Identifiers

PMID28664456
OpenAlexW2730124656

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.