Evidence map›Paper›PMID 28664389›Full record

Trial reportLasers in medical science2017

Preliminary study in a new protocol for the treatment of oral mucositis in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT) and chemotherapy (CT).

Marina Consuelo Vitale, Carola Modaffari, Nunzia Decembrino, Feng Xiao Zhou, Marco Zecca, Patrizia Defabianis

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Lasers in medical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 9 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 9 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Efficacy of photobiomodulation in the treatment of oral mucositis in patients undergoing antineoplastic therapy: systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  3. Pooled it
  4. Non-pharmacological management of infant and young child procedural pain.The Cochrane database of systematic reviews · 2023
    Pooled it
  5. Pooled it
  6. Systematic review of photobiomodulation for the management of oral mucositis in cancer patients and clinical practice guidelines.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Pooled it
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  10. Review
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  13. Nursing care approaches to oral mucositis in pediatric oncology clinics: a cross-sectional study from Türkiye.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Comparative study of royal jelly, propolis, and photobiomodulation therapies in 5-fluorouracil-related oral mucositis in rats.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Marina Consuelo VitaleDepartment of Clinical, Surgical, Diagnostic and Paediatric Sciences, Section of Dentistry, Unit of Orthodontics and Paediatric Dentistry, University of Pavia, Pavia, Italy. m.c.vitale@unipv.it.ORCID http://orcid.org/0000-0003-2531-0286
Carola ModaffariDepartment of Clinical, Surgical, Diagnostic and Paediatric Sciences, Section of Dentistry, Unit of Orthodontics and Paediatric Dentistry, University of Pavia, Pavia, Italy.
Nunzia DecembrinoOnco-Haematological Paediatric Division, IRCSS S. Matteo, Pavia, Italy.
Feng Xiao ZhouDepartment of Clinical, Surgical, Diagnostic and Paediatric Sciences, Section of Dentistry, Unit of Orthodontics and Paediatric Dentistry, University of Pavia, Pavia, Italy.
Marco ZeccaOnco-Haematological Paediatric Division, IRCSS S. Matteo, Pavia, Italy.
Patrizia DefabianisSection of Paediatric Dentistry CIR-Dental School, University of Turin, Turin, Italy.
University of Pavia · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral mucositis (OM) is a debilitating and serious side effect in patients undergoing hematopoietic stem cell transplantation (HSCT) and chemotherapy (CT). Laser therapy is becoming a promising treatment option in these patients, avoiding the necessity of enteral/parenteral nutrition. The aim of this study was to evaluate the efficacy of laser therapy in patients affected by oral mucositis induced by chemotherapy and HSCT. Sixteen onco-hematological pediatric patients receiving chemotherapy and hematopoietic stem cell transplantation, affected by oral mucositis, were enrolled in this study. They were divided in two randomized groups: the laser group and the placebo-control group. Patients in the laser group were treated with HPLT (970 ± 15 nm, 3.2 W (50%), 35-6000 Hz, 240 s) for four consecutive days, once a day; and placebo group underwent sham treatment. The assessment of mucositis was recorded through WHO Oral Mucositis Grading Objective Scale, and pain was evaluated through Visual Analogue Scale (VAS). Patients were monitored and evaluated 3, 7, and 11 days after the first day of laser therapy. Once OM was diagnosed, the patients had mucositis grading assessments before laser or sham application at day 3, 7, and 11 after first application. All patients of laser group demonstrated improvement in pain sensation from day 3 after first application of laser (p < 0.05), ulcerations reduced their dimensions and erythema disappeared. The patients of placebo group had improvement from day 7. In laser group, all mucositis were fully resolved from day 7 (p < 0.05). Oral mucositis negatively impacts on nutritional intake, oral hygiene, and quality of life. Laser therapy appears to be a safe and innovative approach in the management of oral mucositis. In this preliminary study, HPLT encourages to consider laser therapy as a part of onco-hematological protocol, providing to decrease pain and duration of OM induced by CT and HSCT. Further researches will be needed, especially randomized, controlled clinical trials with a large number of enrolled patients and a long term of follow-up to confirm the efficacy of laser therapy in prevention and control of OM in onco-hematological pediatric patients.

Indexed as

Laser TherapyAdolescentAntineoplastic AgentsChildChild, PreschoolFemaleHematopoietic Stem Cell TransplantationHumansMalePain MeasurementQuality of LifeStomatitisVisual Analog ScaleAntineoplastic AgentsLaser therapyOral mucositisPediatric patients

Identifiers

PMID28664389
OpenAlexW2725359183

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.