ArticleEuropean journal of clinical pharmacology2017
Adverse cardiac events associated with incident opioid drug use among older adults with COPD.
Article in European journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Risk of hospitalization and opioid use in older people with dementia.BMC geriatrics · 2026Article
- Indicators of publicly funded prescription opioid use among persons with traumatic spinal cord injury in Ontario, Canada.The journal of spinal cord medicine · 2023Article
- Knowledge, attitudes, and practices toward cancer pain management amongst healthcare workers (physicians, pharmacists, and nurses): a cross-sectional study from first-tier cities in China.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Maternal Complications and Prescription Opioid Exposure During Pregnancy: Using Marginal Structural Models.Drug safety · 2021Article
- Association of Nonacute Opioid Use and Cardiovascular Diseases: A Scoping Review of the Literature.Journal of the American Heart Association · 2021Article
- Survival implications of prescription opioid and benzodiazepine use in lung transplant recipients: Analysis of linked transplant registry and pharmacy fill records.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021Article
- Initial Patterns of Prescription Opioid Supply and Risk of Mortality Among Insured Adults in the United States.Journal of addiction medicine · 2021Observational
- Predictors of Morphine Efficacy for Dyspnea in Inpatients with Chronic Obstructive Pulmonary Disease: A Secondary Analysis of JORTC-PAL 07.Palliative medicine reports · 2021Article
- Combined effect of posttraumatic stress disorder and prescription opioid use on risk of cardiovascular disease.European journal of preventive cardiology · 2020Article
- Evaluation of opioid discontinuation after non-orthopaedic surgery among chronic opioid users: a population-based cohort study.British journal of anaesthesia · 2020Article
- Dyspnea in COPD: New Mechanistic Insights and Management Implications.Advances in therapy · 2020Review
- Association of Opioid and Benzodiazepine Use with Adverse Respiratory Events in Older Adults with Chronic Obstructive Pulmonary Disease.Annals of the American Thoracic Society · 2019Article
- New Coprescription of Opioids and Benzodiazepines and Mortality Among Veterans Affairs Patients With Posttraumatic Stress Disorder.The Journal of clinical psychiatry · 2019Article
- [Another "War on Drugs" : A war against addicts and a "roll-back" for patients needing opioids?]Schmerz (Berlin, Germany) · 2018Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe evaluated whether incident opioid drug use was associated with adverse cardiac events among older adults with chronic obstructive pulmonary disease (COPD).
methodsThis was an exploratory, retrospective cohort study using health administrative data from Ontario, Canada, from 2008 to 2013. Using a validated algorithm, we identified adults aged 66 years and older with non-palliative COPD. Hazard ratios (HR) were estimated for adverse cardiac events within 30 days of incident opioid receipt compared to controls using inverse probability of treatment weighting using the propensity score.
resultsThere were 134,408 community-dwelling individuals and 14,685 long-term care residents with COPD identified, 67.0 and 60.6% of whom received an incident opioid. Incident use of any opioid was associated with significantly decreased rates of emergency room (ER) visits and hospitalizations for congestive heart failure (CHF) among community-dwelling older adults (HR 0.84; 95% CI 0.73-0.97), but significantly increased rates of ischemic heart disease (IHD)-related mortality among long-term care residents (HR 2.15; 95% CI 1.50-3.09). In the community-dwelling group, users of more potent opioid-only agents without aspirin or acetaminophen combined had significantly increased rates of ER visits and hospitalizations for IHD (HR 1.38; 95% CI 1.08-1.77) and IHD-related mortality (HR 1.83; 95% CI 1.32-2.53).
conclusionsNew opioid use was associated with elevated rates of IHD-related morbidity and mortality among older adults with COPD. Adverse cardiac events may need to be considered when administering new opioids to older adults with COPD, but further studies are required to establish if the observed associations are causal or related to residual confounding.
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