Evidence map›Paper›PMID 28664245›Full record

ArticleEuropean radiology2018

A semiquantitative MRI-Score can predict loss of lung function in patients with cystic fibrosis: Preliminary results.

Juergen F Schaefer, Andreas Hector, Katharina Schmidt, Matthias Teufel, Sabrina Fleischer, Ute Graepler-Mainka, Joachim Riethmueller, Sergios Gatidis, Susanne Schaefer, Konstantin Nikolaou and 2 more

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In one paragraph

Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Sensitive structural and functional measurements and 1-year pulmonary outcomes in pediatric cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2021
    Article
  7. Review
  8. Article
  9. Imaging of Airway Obstruction in Children.Frontiers in pediatrics · 2020
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Juergen F SchaeferDepartment of Diagnostic and Interventional Radiology, University Hospital of Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany. juergen.schaefer@med.uni-tuebingen.de.
Andreas HectorDepartment of Paediatrics I, University Children's Hospital of Tuebingen, Tuebingen, Germany.
Katharina SchmidtDepartment of Diagnostic and Interventional Radiology, University Hospital of Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.
Matthias TeufelDepartment of Diagnostic and Interventional Radiology, University Hospital of Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.
Sabrina FleischerDepartment of Diagnostic and Interventional Radiology, University Hospital of Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.
Ute Graepler-MainkaDepartment of Paediatrics I, University Children's Hospital of Tuebingen, Tuebingen, Germany.
Joachim RiethmuellerDepartment of Paediatrics I, University Children's Hospital of Tuebingen, Tuebingen, Germany.
Sergios GatidisDepartment of Diagnostic and Interventional Radiology, University Hospital of Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.
Susanne SchaeferDepartment of Diagnostic and Interventional Radiology, University Hospital of Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.
Konstantin NikolaouDepartment of Diagnostic and Interventional Radiology, University Hospital of Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.
Dominik HartlDepartment of Paediatrics I, University Children's Hospital of Tuebingen, Tuebingen, Germany.
Ilias TsiflikasDepartment of Diagnostic and Interventional Radiology, University Hospital of Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the applicability of a semiquantitative MRI scoring system (MR-CF-S) as a prognostic marker for clinical course of cystic fibrosis (CF) lung disease.

methodsThis observational study of a single-centre CF cohort included a group of 61 patients (mean age 12.9 ± 4.7 years) receiving morphological and functional pulmonary MRI, pulmonary function testing (PFT) and follow-up of 2 years. MRI was analysed by three raters using MR-CF-S. The inter-rater agreement, correlation of score categories with forced expiratory volume in 1 s (FEV

resultsThe inter-rater agreement of MR-CF-S was sufficient (mean intraclass correlation coefficient 0.92). MR-CF-S (-0.62; p < 0.05) and most of the categories significantly correlated with FEV

conclusionsMR-CF-S is promising to predict a loss of lung function. CO seems to be a particular finding in CF patients with an abnormal course. KEY POINTS: • Lung imaging is essential in the diagnostic work-up of CF patients • MRI serves as a powerful, radiation-free modality in paediatric CF patients • Observational single-centre study showed significant correlation of MR-CF score and FEV

Indexed as

AdolescentChildCystic FibrosisFemaleForced Expiratory VolumeHumansLungMagnetic Resonance ImagingMaleRespiratory Function TestsROC CurveForced expiratory volumeMagnetic resonance imagingPaediatricsPulmonary cystic fibrosisRespiratory function tests

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.