Evidence map›Paper›PMID 28664196›Full record

ArticlePain reports2016

Postinflammatory hyperpigmentation after human cold pain testing.

Melissa J Wolz, Katelyn E Sadler, Caela C Long, Daniel S Brenner, Brian S Kim, Robert W Gereau, Benedict J Kolber

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Melissa J WolzDepartment of Biological Sciences and Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA, USA.
Katelyn E SadlerDepartment of Biological Sciences and Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA, USA.
Caela C LongDepartment of Biological Sciences and Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA, USA.
Daniel S BrennerWashington University Pain Center and Department of Anesthesiology, St. Louis, MO, USA.
Brian S KimCenter for the Study of Itch, Washington University in St. Louis, St. Louis, MO, USA.
Robert W GereauWashington University Pain Center and Department of Anesthesiology, St. Louis, MO, USA.
Benedict J KolberDepartment of Biological Sciences and Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA, USA.
Duquesne University · USWashington University in St. Louis · US

Funding

Effects of Central Amygdala Lateralization on Descending Control of Bladder PainF31DK104538 · NIDDK · DUQUESNE UNIVERSITY · PI SADLER, KATELYN · 2014 to 2016
$97k
NIDDK NIH HHS F31 DK104538
6 · The paper itself

Abstract

Changes in cold temperature sensitivity are often associated with chronic pain conditions. Progress in understanding the neurobiological mechanism underlying these changes and resulting development of effective therapies has been slowed by the accessibility and affordability of devices used to measure thermal sensitivity in humans. To address this gap, we developed an inexpensive method to measure cold pain thresholds in healthy adult volunteers using dry ice and a thermode. However, early in preliminary testing, a subject presented with epidermal postinflammatory hyperpigmentation that lasted for >200 days. Although this response was unique among the small number of subjects in development of the assay, it raised questions as to the safety of the assay design.

Indexed as

Adverse eventCold painHuman testingHypersensitivityPostinflammatory hyperpigmentation

Identifiers

PMID28664196
PMCPMC5486980
OpenAlexW2513931619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.